WEKO3
アイテム
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報酬に基づく行動におけるセロトニンの制御に関する研究
https://doi.org/10.15102/1394.00002295
https://doi.org/10.15102/1394.0000229563d39d8c-7acc-401d-a484-9b1f10f6255b
名前 / ファイル | ライセンス | アクション |
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Taira_FullText (5.0 MB)
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Taira_FinalExamAbstract (42.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2022-02-09 | |||||||
タイトル | ||||||||
言語 | ja | |||||||
タイトル | 報酬に基づく行動におけるセロトニンの制御に関する研究 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | The Role of Serotonin Neurons in Mouse Reward-based Behaviors | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
ID登録 | ||||||||
ID登録 | 10.15102/1394.00002295 | |||||||
ID登録タイプ | JaLC | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 (英) |
Taira, Masakazu
× Taira, Masakazu
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抄録 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Serotonin (5-HT) is an important neuromodulator in reward-driven learning and decision making. The dorsal raphe nucleus (DRN) sends diffuse 5-HT projections throughout the brain. The involvement of DRN 5-HT neurons in reward-based behaviors has been examined using various types of behavioral tasks; however, how DRN 5-HT affects computational processes of decision making remains unclear. Reinforcement learning (RL) is a theoretical framework to describe the decision making process. Previous studies based on the RL framework have proposed hypotheses on the role of 5-HT in decision making, such as temporal discounting and model-based value computation. The overall aim of this thesis is to examine these hypotheses by analyzing behaviors under optogenetic manipulation, thereby clarifying the role of DRN 5-HT neurons in reward-based behaviors. The first hypothesis is that 5-HT modulates the relative importance of future rewards. Previous behavioral studies showed that 5-HT activation enhances patience to wait for future rewards and vice versa. However, how 5-HT regulates persistence to act for future rewards remains unknown. In the first part of my thesis research, I trained mice to perform a free-operant lever-pressing task, in which motor action rather than stationary waiting was required to obtain delayed rewards. In testing the effects of optogenetic activation and inhibition of 5-HT neurons on sustained motor actions, I found that optogenetic activation or inhibition of 5-HT neurons did not affect persistence in motor actions but an effect of the activation on slowing down response vigor, suggesting a different role of 5-HT neurons in motor actions for future rewards compared to stationary waiting. The second hypothesis examined is that 5- HT affects model-based decision making. In model-based decision making, agents use their own internal models of action-outcome relationships to plan forward and to select actions. Previous computational studies proposed facilitation of model-based decision making by 5-HT neurons, but behavioral evidence of how 5-HT regulates the process is still limited. A two-step decision making task is an established behavioral task to understand model-based decision making. In the second half of my thesis project, I trained mice to perform the two-step decision making task and found that optogenetic inhibition of 5-HT neurons affected choice behaviors and reduced time to make decisions possibly reflecting the disruption of model-based decision making. By fitting behavioral data to a model-free/model-based hybrid model, I found that photoinhibition of 5-HT neurons decreased the weight of model-based decision making. These results revealed the role of 5-HT neurons reward-based behaviors and model-based computations. | |||||||
口頭試問日 | ||||||||
2021-12-08 | ||||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2022-01-31 | |||||||
学位名 | ||||||||
学位名 | Doctor of Philosophy | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第86号 | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 38005 | |||||||
学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
権利 | ||||||||
権利情報 | © 2022 The Author. |