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Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage
https://oist.repo.nii.ac.jp/records/2574
https://oist.repo.nii.ac.jp/records/2574b5c69e74-1358-49bd-b12d-8a5b95770ae8
名前 / ファイル | ライセンス | アクション |
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elife-70990-v2 (9.3 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-02-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cell biology | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chromosome pairing | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | comparative cell biology | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | genetics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | genomics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | meiosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | meiotic recombination | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | pristionchus pacificus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Rillo-Bohn, Regina
× Rillo-Bohn, Regina× Adilardi, Renzo× Mitros, Therese× Avşaroğlu, Barış× Stevens, Lewis× Köhler, Simone× Bayes, Joshua× Wang, Clara× Lin, Sabrina× Baskevitch, K Alienor× Rokhsar, Daniel S× Dernburg, Abby F |
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書誌情報 |
en : eLife 巻 10, p. e70990, 発行日 2021-08-24 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Meiosis is conserved across eukaryotes yet varies in the details of its execution. Here we describe a new comparative model system for molecular analysis of meiosis, the nematode Pristionchus pacificus, a distant relative of the widely studied model organism Caenorhabditis elegans. P. pacificus shares many anatomical and other features that facilitate analysis of meiosis in C. elegans. However, while C. elegans has lost the meiosis-specific recombinase Dmc1 and evolved a recombination-independent mechanism to synapse its chromosomes, P. pacificus expresses both DMC-1 and RAD-51. We find that SPO-11 and DMC-1 are required for stable homolog pairing, synapsis, and crossover formation, while RAD-51 is dispensable for these key meiotic processes. RAD-51 and DMC-1 localize sequentially to chromosomes during meiotic prophase and show nonoverlapping functions. We also present a new genetic map for P. pacificus that reveals a crossover landscape very similar to that of C. elegans, despite marked divergence in the regulation of synapsis and crossing-over between these lineages. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34427184 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.70990 | |||||
権利 | ||||||
権利情報 | © 2021 Rillo-Bohn et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/70990 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |