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State-dependent representations of mixtures by the olfactory bulb
https://oist.repo.nii.ac.jp/records/2657
https://oist.repo.nii.ac.jp/records/265767616117-578e-4397-a74f-fa45b49e7845
名前 / ファイル | ライセンス | アクション |
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elife-76882-v2 (6.7 MB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-06-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | State-dependent representations of mixtures by the olfactory bulb | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Reinert, Janine Kristin
× Reinert, Janine Kristin× Lindeman, Sander× Adefuin, Aliya Mari× Fukunaga, Izumi |
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書誌情報 |
en : eLife 巻 11, p. e76882, 発行日 2022-03-07 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Sensory systems are often tasked to analyse complex signals from the environment, separating relevant from irrelevant parts. This process of decomposing signals is challenging when a mixture of signals does not equal the sum of its parts, leading to an unpredictable corruption of signal patterns. In olfaction, nonlinear summation is prevalent at various stages of sensory processing. Here, we investigate how the olfactory system deals with binary mixtures of odours under different brain states by two-photon imaging of olfactory bulb (OB) output neurons. Unlike previous studies using anaesthetised animals, we found that mixture summation is more linear in the early phase of evoked responses in awake, head-fixed mice performing an odour detection task, due to dampened responses. Despite smaller and more variable responses, decoding analyses indicated that the data from behaving mice was well discriminable. Curiously, the time course of decoding accuracy did not correlate strictly with the linearity of summation. Further, a comparison with naïve mice indicated that learning to accurately perform the mixture detection task is not accompanied by more linear mixture summation. Finally, using a simulation, we demonstrate that, while saturating sublinearity tends to degrade the discriminability, the extent of the impairment may depend on other factors, including pattern decorrelation. Altogether, our results demonstrate that the mixture representation in the primary olfactory area is state-dependent, but the analytical perception may not strictly correlate with linearity in summation. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/35254262 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.76882 | |||||
権利 | ||||||
権利情報 | © Adefuin et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/76882 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |