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Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons
https://oist.repo.nii.ac.jp/records/2754
https://oist.repo.nii.ac.jp/records/2754b231059b-d45e-4e14-a2ce-631bd9995ed7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hayakawa-Mass spectrometry of short peptides r (12.3 MB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-08-22 | |||||
| タイトル | ||||||
| タイトル | Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Hayakawa, Eisuke
× Hayakawa, Eisuke× Guzman, Christine× Horiguchi, Osamu× Kawano, Chihiro× Shiraishi, Akira× Mohri, Kurato× Lin, Mei-Fang× Nakamura, Ryotaro× Nakamura, Ryo× Kawai, Erina× Komoto, Shinya× Jokura, Kei× Shiba, Kogiku× Shigenobu, Shuji× Satake, Honoo× Inaba, Kazuo× Watanabe, Hiroshi |
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| 書誌情報 |
en : Nature Ecology & Evolution 発行日 2022-08-08 |
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| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The evolutionary origins of neurons remain unknown. Although recent genome data of extant early-branching animals have shown that neural genes existed in the common ancestor of animals, the physiological and genetic properties of neurons in the early evolutionary phase are still unclear. Here, we performed a mass spectrometry-based comprehensive survey of short peptides from early-branching lineages Cnidaria, Porifera and Ctenophora. We identified a number of mature ctenophore neuropeptides that are expressed in neurons associated with sensory, muscular and digestive systems. The ctenophore peptides are stored in vesicles in cell bodies and neurites, suggesting volume transmission similar to that of cnidarian and bilaterian peptidergic systems. A comparison of genetic characteristics revealed that the peptide-expressing cells of Cnidaria and Ctenophora express the vast majority of genes that have pivotal roles in maturation, secretion and degradation of neuropeptides in Bilateria. Functional analysis of neuropeptides and prediction of receptors with machine learning demonstrated peptide regulation of a wide range of target effector cells, including cells of muscular systems. The striking parallels between the peptidergic neuronal properties of Cnidaria and Bilateria and those of Ctenophora, the most basal neuron-bearing animals, suggest a common evolutionary origin of metazoan peptidergic nervous systems. | |||||
| 出版者 | ||||||
| 出版者 | Nature Portfolio | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2397-334X | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/35941202 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1038/s41559-022-01835-7 | |||||
| 権利 | ||||||
| 権利情報 | © 2022 The Author(s) | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41559-022-01835-7 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
