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Control cell migration by engineering integrin ligand assembly
https://oist.repo.nii.ac.jp/records/2777
https://oist.repo.nii.ac.jp/records/2777aa99f375-139d-4e9a-b0cc-cd34759f3e63
名前 / ファイル | ライセンス | アクション |
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s41467-022-32686-2 (1) (15.0 MB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-09-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Control cell migration by engineering integrin ligand assembly | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Hu, Xunwu
× Hu, Xunwu× Roy, Sona Rani× Jin, Chengzhi× Li, Guanying× Zhang, Qizheng× Asano, Natsuko× Asahina, Shunsuke× Kajiwara, Tomoko× Takahara, Atsushi× Feng, Bolu× Aoki, Kazuhiro× Xu, Chenjie× Zhang, Ye |
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書誌情報 |
en : Nature Communications 巻 13, 号 1, p. 5002, 発行日 2022-08-25 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration. Top-down nanopatterning limited the spatial presentation to sub-micron placing restrictions on both fundamental study and biomedical applications. To break the constraint, here we propose a bottom-up nanofabrication strategy to enhance the spatial resolution to the molecular level using simple formulation that is applicable as treatment agent. Via self-assembly and co-assembly, precise control of ligand presentation is succeeded by varying the proportions of assembling ligand and nonfunctional peptide. Assembled nanofilaments fulfill multi-functions exerting enhancement to suppression effect on cell migration with tunable amplitudes. Self-assembled nanofilaments possessing by far the highest ligand density prevent integrin/actin disassembly at cell rear, which expands the perspective of ligand-density-dependent-modulation, revealing valuable inputs to therapeutic innovations in tumor metastasis. | |||||
出版者 | ||||||
出版者 | Nature Portfolio | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/36008449 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-022-32686-2 | |||||
権利 | ||||||
権利情報 | © 2022 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-022-32686-2 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |