WEKO3
アイテム
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Biodegradable and electrically conductive melanin‐Poly (3‐hydroxybutyrate) 3D fibrous scaffolds for neural tissue engineering applications
https://oist.repo.nii.ac.jp/records/2788
https://oist.repo.nii.ac.jp/records/2788ba89015b-5562-4902-b30d-362db1ef02f4
名前 / ファイル | ライセンス | アクション |
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Agrawal-Biodegradable and electrically conduct (4.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-09-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Biodegradable and electrically conductive melanin‐Poly (3‐hydroxybutyrate) 3D fibrous scaffolds for neural tissue engineering applications | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Electrospinning | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fibrous scaffolds | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | electroconductive | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | biodegradable | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | melanin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Poly (3hydroxybutyrate) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neural tissue engineering | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Agrawal, Lokesh
× Agrawal, Lokesh× Vimal, Sunil Kumar× Barzaghi, Paolo× Takashi, Shiga× Terenzio, Marco |
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書誌情報 |
en : Macromolecular Bioscience p. 2200315, 発行日 2022-09-28 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Due to the severity of peripheral nerve and spinal cord injuries, treatment options for patients are limited. In this context, biomaterials designed to promote regeneration and reinstate the lost function are being explored. Such biomaterials should be able to mimic the biological, chemical, and physical cues of the extracellular matrix for maximum effectiveness as therapeutic agents. Development of biomaterials with desirable physical, chemical, and electrical properties, however, has proven challenging. Here, we propose a novel biomaterial formulation achieved by blending the pigment melanin and the natural polymer Poly (3-hydroxybutyrate). Physio-chemical measurements of electrospun fibers revealed a feature rich surface nano-topography, a semiconducting-nature and brain-tissue-like poroviscoelastic properties. Resulting fibers improved cell adhesion and growth of mouse sensory and motor neurons, without any observable toxicity. Further, the presence of polar functional groups positively affected the kinetics of fibers degradation at a pH (∼7.4) comparable to that of body fluids. Thus, melanin-PHB blended scaffolds were found to be physio-chemically, electrically, and biologically compatible with neural tissues and could be used as a regenerative modality for neural tissue injuries. | |||||
出版者 | ||||||
出版者 | John Wiley & Sons, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1616-5187 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1616-5195 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/36114714 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1002/mabi.202200315 | |||||
権利 | ||||||
権利情報 | © 2022 Wiley-VCH GmbH | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Agrawal, L., Vimal, S. K., Barzaghi, P., Takashi, S., Terenzio, M., Biodegradable and electrically conductive melanin-Poly (3-hydroxybutyrate) 3D fibrous scaffolds for neural tissue engineering applications. Macromol. Biosci. 2022, 2200315., which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200315. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200315 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |