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嗅覚における図地分離機構の解明を目的とする実験手法の確立
https://doi.org/10.15102/1394.00002540
https://doi.org/10.15102/1394.0000254078c26bcc-d6ee-42a5-8b3e-8a302f7c7f30
名前 / ファイル | ライセンス | アクション |
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Purser-FullText (9.9 MB)
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Purser-FinalExamAbstract (42.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2022-10-05 | |||||||
タイトル | ||||||||
言語 | ja | |||||||
タイトル | 嗅覚における図地分離機構の解明を目的とする実験手法の確立 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Designing a Tractable Behavioral Paradigm for Investigating Olfactory Figure-ground Segregation | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
ID登録 | ||||||||
ID登録 | 10.15102/1394.00002540 | |||||||
ID登録タイプ | JaLC | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 (英) |
Purser, Aliya Mari
× Purser, Aliya Mari
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抄録 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Odors naturally exist as mixtures in the environment. Detecting relevant cues amidst other signals and noise, a task called figure-ground segregation, is important for survival. Understanding mechanisms that enable animals to solve such a challenging task requires a paradigm that recapitulates key features of the task, yet ideally should be simple enough that allows these mechanistic bases to be studied experimentally. In my PhD, I developed a behavioral paradigm using only binary mixtures as a model for olfactory figure-ground segregation in mice. Ethyl butyrate (EB) was assigned as target odor and ten other background odors with differing degrees of chemical similarity to EB were included as part of a Go/No-Go task. The fact that the mixtures comprised only two odors made the number of possible odor combinations limited, which therefore made the paradigm tractable and ensured that all combinations can be presented exhaustively per behavioral session. Despite its simplicity, I demonstrate that the experimental paradigm can still impose a degree of challenge for mice through the use of a highly similar background odor. This captures recent findings that the degree of overlap between odor-evoked neural representations underlies figure-ground segregation difficulty. Additionally, it was determined that mice performing the binary mixture task can easily generalize when presented with a novel odor, which suggests that demixing is likely involved. Finally, two example cases are presented as examples how the experimental paradigm can be applied to investigate possible neural mechanisms of olfactory figure-ground segregation. Overall, despite its simplicity, the experimental paradigm using only binary mixtures may be used to probe neural mechanisms of olfactory figure-ground segregation. | |||||||
口頭試問日 | ||||||||
2022-09-06 | ||||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2022-09-30 | |||||||
学位名 | ||||||||
学位名 | Doctor of Philosophy | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第104号 | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 38005 | |||||||
学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
権利 | ||||||||
権利情報 | © 2022 The Author. |