WEKO3
アイテム
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Water‐Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome‐Targeted Cancer Photodynamic Therapy
https://oist.repo.nii.ac.jp/records/2817
https://oist.repo.nii.ac.jp/records/28178064caff-c1db-4578-8654-7a5d72e33365
名前 / ファイル | ライセンス | アクション |
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Water-Soluble_am (3.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-10-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Water‐Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome‐Targeted Cancer Photodynamic Therapy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bioimaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer treatment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carbohelicene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nanoparticles | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | photodynamic therapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zhao, Hao
× Zhao, Hao× Xu, Xiushang× Zhou, Long× Hu, Yunbin× Huang, Yiming× Narita, Akimitsu |
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書誌情報 |
en : Small 巻 18, 号 1, p. 2105365, 発行日 2021-11-06 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Helicene-based therapeutic agents for organelle-targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water-soluble nanoparticles containing twisted double [7]carbohelicene (D7H-NPs) are prepared through self-assembly with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] by a nanoprecipitation method. D7H-NPs display high water solubility with an average size of 46 ± 2 nm. Notably, D7H-NPs can generate efficient singlet oxygen (1O2) and superoxide anion (O2· −) upon white light irradiation, forming the basis of PDT. Moreover, the typical accumulation in lysosomes of 4T1 cancer cells paves the way to use D7H-NPs for lysosome-targeted cancer phototherapeutics. This paper reports a promising helicene-based phototherapeutic agent involving both type I and II PDT for organelle-targeted biotherapy. | |||||
出版者 | ||||||
出版者 | Wiley-VCH GmbH | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1613-6810 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1613-6829 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34741415 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1002/smll.202105365 | |||||
権利 | ||||||
権利情報 | © 2021 Wiley-VCH GmbH | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Zhao, H., Xu, X., Zhou, L., Hu, Y., Huang, Y., Narita, A., Water-Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome-Targeted Cancer Photodynamic Therapy. Small 2022, 18, 2105365., which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/smll.202105365. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/10.1002/smll.202105365 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |