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Refinement of learned skilled movement representation in motor cortex deep output layer
https://oist.repo.nii.ac.jp/records/296
https://oist.repo.nii.ac.jp/records/296a6c83f63-2db7-4dcc-b4ba-e455bcfbaffb
名前 / ファイル | ライセンス | アクション |
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ncomms15834 (7.8 MB)
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Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Refinement of learned skilled movement representation in motor cortex deep output layer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Li, Qian
× Li, Qian× Ko, Ho× Qian, Zhong-Ming× Yan, Leo Y. C.× Chan, Danny C. W.× Arbuthnott, Gordon× Ke, Ya× Yung, Wing-Ho |
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書誌情報 |
en : Nature Communications 巻 8, p. 15834, 発行日 2017-06-09 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The mechanisms underlying the emergence of learned motor skill representation in primary motor cortex (M1) are not well understood. Specifically, how motor representation in the deep output layer 5b (L5b) is shaped by motor learning remains virtually unknown. In rats undergoing motor skill training, we detect a subpopulation of task-recruited L5b neurons that not only become more movement-encoding, but their activities are also more structured and temporally aligned to motor execution with a timescale of refinement in tens-of-milliseconds. Field potentials evoked at L5b in vivo exhibit persistent long-term potentiation (LTP) that parallels motor performance. Intracortical dopamine denervation impairs motor learning, and disrupts the LTP profile as well as the emergent neurodynamical properties of task-recruited L5b neurons. Thus, dopamine-dependent recruitment of L5b neuronal ensembles via synaptic reorganization may allow the motor cortex to generate more temporally structured, movement-encoding output signal from M1 to downstream circuitry that drives increased uniformity and precision of movement during motor learning. | |||||
出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28598433 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/ncomms15834 | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/ncomms15834 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |