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Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression
https://oist.repo.nii.ac.jp/records/428
https://oist.repo.nii.ac.jp/records/42804e65487-c8c0-4c51-b1f1-ccfdcf922659
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S2211124718302900-main (2.4 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-07-11 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Yamashita, Manami
× Yamashita, Manami× Kawaguchi, Shin-ya× Hori, Tetsuya× Takahashi, Tomoyuki |
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書誌情報 |
en : Cell Reports 巻 22, 号 12, p. 3134-3141, 発行日 2018-03-20 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a time. Bursts of presynaptic firings depress synaptic efficacy, mainly due to depletion of releasable vesicles, whereas recovery from strong depression is initiated by endocytic vesicle retrieval followed by refilling of vesicles with neurotransmitter. We washed out presynaptic cytosolic GABA to induce a rundown of IPSCs at cerebellar inhibitory cell pairs in slices from rats and then allowed fast recovery by elevating GABA concentration using photo-uncaging. The time course of this recovery coincided with that of IPSCs from activity-dependent depression induced by a train of high-frequency stimulation. We conclude that vesicular GABA uptake can be a limiting step for the recovery of inhibitory neurotransmission from synaptic depression. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29562170 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.celrep.2018.02.080 | |||||
権利 | ||||||
権利情報 | © 2018 The Authors. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2211124718302900?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |