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Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches
https://oist.repo.nii.ac.jp/records/459
https://oist.repo.nii.ac.jp/records/45927c23d3e-77bb-4578-91a9-29ea69f317c6
名前 / ファイル | ライセンス | アクション |
---|---|---|
Neurotoxicity of cGMP in the vertebrate retina from the initial research on rd mutant mice to zebrafish genetic approaches (2.6 MB)
|
Creative Commons Attribution-NonCommercial-NoDerivatives License
(http://creativecommons.org/Licenses/by-nc-nd/ 4.0/), |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-07-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Iribarne, Maria
× Iribarne, Maria× Masai, Ichiro |
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書誌情報 |
en : Journal of Neurogenetics 巻 31, 号 3, p. 88-101, 発行日 2017-08-16 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Zebrafish are an excellent animal model for research on vertebrate development and human diseases. Sophisticated genetic tools including large-scale mutagenesis methodology make zebrafish useful for studying neuronal degenerative diseases. Here, we review zebrafish models of inherited ophthalmic diseases, focusing on cGMP metabolism in photoreceptors. cGMP is the second messenger of phototransduction, and abnormal cGMP levels are associated with photoreceptor death. cGMP concentration represents a balance between cGMP phosphodiesterase 6 (PDE6) and guanylate cyclase (GC) activities in photoreceptors. Various zebrafish cGMP metabolism mutants were used to clarify molecular mechanisms by which dysfunctions in this pathway trigger photoreceptor degeneration. Here, we review the history of research on the retinal degeneration (rd) mutant mouse, which carries a genetic mutation of PDE6b, and we also highlight recent research in photoreceptor degeneration using zebrafish models. Several recent discoveries that provide insight into cGMP toxicity in photoreceptors are discussed. | |||||
出版者 | ||||||
出版者 | Informa UK Limited, trading as Taylor & Francis Group. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0167-7063 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1563-5260 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28812418 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1080/01677063.2017.1358268 | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.tandfonline.com/doi/full/10.1080/01677063.2017.1358268 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |