WEKO3
アイテム
{"_buckets": {"deposit": "d403f311-21b3-4ce0-ade8-62e82fc4fa56"}, "_deposit": {"created_by": 27, "id": "661", "owners": [27], "pid": {"revision_id": 0, "type": "depid", "value": "661"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00000661", "sets": ["68"]}, "author_link": ["2995", "2998", "2996", "2994", "2997", "2999"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-01-23", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "1205", "bibliographicPageStart": "1194", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{}, {"bibliographic_title": "European Journal of Neuroscience", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Aoki, Sho"}], "nameIdentifiers": [{"nameIdentifier": "2994", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liu, Andrew W."}], "nameIdentifiers": [{"nameIdentifier": "2995", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akamine, Yumiko"}], "nameIdentifiers": [{"nameIdentifier": "2996", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zucca, Aya"}], "nameIdentifiers": [{"nameIdentifier": "2997", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zucca, Stefano"}], "nameIdentifiers": [{"nameIdentifier": "2998", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wickens, Jeffery R."}], "nameIdentifiers": [{"nameIdentifier": "2999", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "Behavioural flexibility is crucial for adaptive behaviour, and recent evidence suggests that cholinergic interneurons of the striatum play a distinct role. Previous studies of cholinergic function have focused on strategy switching by the dorsomedial or ventral striatum. We here investigated whether cholinergic interneurons in the dorsolateral striatum play a similar role at the level of switching of habitual responses. Because the dorsolateral striatum is particularly involved in habitual responding, we developed a habit substitution task that involved switching habitual lever‐press responses to one side to another. We first measured the effect of cholinergic activation in the dorsolateral striatum on this task. Chemogenetic activation of cholinergic interneurons caused an increase in the response rate for the substituted response that was significantly greater than the increase normally seen in control animals. The increase was due to burst‐like responses with shorter inter‐press intervals. However, there was no effect on inhibiting the old habit, or on habitual responding that did not require a switch. There was also no effect on lever‐press performance and its reversal before lever‐press responses became habitual. Conversely, neurochemically specific ablation of cholinergic interneurons did not significantly change habitual responding or response substitution. Thus, activation –but not ablation –of cholinergic interneurons in the dorsolateral striatum modulates expression of a new habit when an old habit is replaced by a new one. Together with previous work, this suggests that striatal cholinergic interneurons facilitate behavioural flexibility in both dorsolateral striatum in addition to dorsomedial and ventral striatum.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "John Wiley and Sons"}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/29359362", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1111/ejn.13820", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.13820", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2018 The Author(s)."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1460-9568", "subitem_source_identifier_type": "ISSN"}, {"subitem_source_identifier": "0953-816X", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-08-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Aoki_et_al-2018-European_Journal_of_Neuroscien.pdf", "filesize": [{"value": "5.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/", "licensetype": "license_free", "mimetype": "application/pdf", "size": 5900000.0, "url": {"label": "Aoki_et_al-2018-European_Journal_of_Neuroscien", "url": "https://oist.repo.nii.ac.jp/record/661/files/Aoki_et_al-2018-European_Journal_of_Neuroscien.pdf"}, "version_id": "4b7c9f77-4861-4b0f-820f-f1c7d58f3fb3"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cholinergic interneurons in the rat striatum modulate substitution of habits", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cholinergic interneurons in the rat striatum modulate substitution of habits", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "27", "path": ["68"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/661", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-08-14"}, "publish_date": "2018-08-14", "publish_status": "0", "recid": "661", "relation": {}, "relation_version_is_last": true, "title": ["Cholinergic interneurons in the rat striatum modulate substitution of habits"], "weko_shared_id": 27}
Cholinergic interneurons in the rat striatum modulate substitution of habits
https://oist.repo.nii.ac.jp/records/661
https://oist.repo.nii.ac.jp/records/66153a0f7d4-f315-4fc7-9bd5-7cec1419f2e3
名前 / ファイル | ライセンス | アクション |
---|---|---|
Aoki_et_al-2018-European_Journal_of_Neuroscien (5.9 MB)
|
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-08-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cholinergic interneurons in the rat striatum modulate substitution of habits | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Aoki, Sho
× Aoki, Sho× Liu, Andrew W.× Akamine, Yumiko× Zucca, Aya× Zucca, Stefano× Wickens, Jeffery R. |
|||||
書誌情報 |
en : European Journal of Neuroscience 巻 47, 号 10, p. 1194-1205, 発行日 2018-01-23 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Behavioural flexibility is crucial for adaptive behaviour, and recent evidence suggests that cholinergic interneurons of the striatum play a distinct role. Previous studies of cholinergic function have focused on strategy switching by the dorsomedial or ventral striatum. We here investigated whether cholinergic interneurons in the dorsolateral striatum play a similar role at the level of switching of habitual responses. Because the dorsolateral striatum is particularly involved in habitual responding, we developed a habit substitution task that involved switching habitual lever‐press responses to one side to another. We first measured the effect of cholinergic activation in the dorsolateral striatum on this task. Chemogenetic activation of cholinergic interneurons caused an increase in the response rate for the substituted response that was significantly greater than the increase normally seen in control animals. The increase was due to burst‐like responses with shorter inter‐press intervals. However, there was no effect on inhibiting the old habit, or on habitual responding that did not require a switch. There was also no effect on lever‐press performance and its reversal before lever‐press responses became habitual. Conversely, neurochemically specific ablation of cholinergic interneurons did not significantly change habitual responding or response substitution. Thus, activation –but not ablation –of cholinergic interneurons in the dorsolateral striatum modulates expression of a new habit when an old habit is replaced by a new one. Together with previous work, this suggests that striatal cholinergic interneurons facilitate behavioural flexibility in both dorsolateral striatum in addition to dorsomedial and ventral striatum. | |||||
出版者 | ||||||
出版者 | John Wiley and Sons | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1460-9568 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0953-816X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29359362 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1111/ejn.13820 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.13820 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |