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Large-Scale Nanophotonic Structures for Long-Term Monitoring of Cell Proliferation
https://oist.repo.nii.ac.jp/records/675
https://oist.repo.nii.ac.jp/records/675021deee0-b6f0-4208-a1f2-f560fa7e46fe
名前 / ファイル | ライセンス | アクション |
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Manuscript-production (976.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-01-20 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Large-Scale Nanophotonic Structures for Long-Term Monitoring of Cell Proliferation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Bhalla, Nikhil
× Bhalla, Nikhil× Sathish, Shivani× Sinha, Abhishek× Shen, Amy Q. |
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書誌情報 |
en : Advanced Biosystems 巻 2, 号 4, p. 1700258, 発行日 2018-01-19 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Innovative sensing materials have enabled the discovery of cell biology principles at the nanoscale. In order to evaluate cell behavior and responses, it is necessary to accurately monitor cell proliferation. However, it remains challenging to develop nanomaterials possessing pertinent properties for sensing, while ensuring long‐term cell survival and unaltered cellular responses. This work develops highly sensitive, large‐scale, and biocompatible nanoplasmonic biosensors for long‐term monitoring of cell proliferation, reported for the first time. The nanoplasmonic sensor consists of mushroom‐like structures, with stems of silicon dioxide and caps of gold covering a total surface area of 18.75 cm2. The localized surface plasmons on the nanomushroom caps are exploited to monitor proliferating fibroblast cells. Changes in nanoplasmonic resonances of the nanomushrooms are directly proportional to the number of cells that bind to them. Fibroblast proliferation is successfully monitored for 7 d, demonstrating remarkable biocompatibility of the nanomushroom substrates. These nanomushroom substrates preserve cell viability and serve as a label‐free platform for long‐term monitoring of cell proliferation. These results also open new opportunities in developing standard cell assays without chemical labels to detect cellular responses at the nanoscale. | |||||
出版者 | ||||||
出版者 | John Wiley and Sons | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2366-7478 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1002/adbi.201700258 | |||||
権利 | ||||||
権利情報 | © 2018 WILEY‐VCH Verlag GmbH & Co. | |||||
権利 | ||||||
権利情報 | This is the accepted version of the following article: Bhalla, N., Sathish, S., Sinha, A., Shen, A. Q., Adv. Biosys. 2018, 2, 1700258. https://doi.org/10.1002/adbi.201700258 , which has been published in final form at https://doi.org/10.1002/adbi.201700258. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/abs/10.1002/adbi.201700258 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |