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Switching On Depression and Potentiation in the Cerebellum
https://oist.repo.nii.ac.jp/records/677
https://oist.repo.nii.ac.jp/records/6778d55d9cc-ce62-4848-91c8-680489955e23
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S2211124717319216-main (2.8 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives License
(http://creativecommons.org/Licenses/by-nc-nd/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-08-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Switching On Depression and Potentiation in the Cerebellum | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Gallimore, Andrew R.
× Gallimore, Andrew R.× Kim, Taegon× Tanaka-Yamamoto, Keiko× De Schutter, Erik |
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書誌情報 |
en : Cell Reports 巻 22, 号 3, p. 722-733, 発行日 2018-01-16 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Long-term depression (LTD) and long-term potentiation (LTP) in the cerebellum are important for motor learning. However, the signaling mechanisms controlling whether LTD or LTP is induced in response to synaptic stimulation remain obscure. Using a unified model of LTD and LTP at the cerebellar parallel fiber-Purkinje cell (PF-PC) synapse, we delineate the coordinated pre- and postsynaptic signaling that determines the direction of plasticity. We show that LTP is the default response to PF stimulation above a well-defined frequency threshold. However, if the calcium signal surpasses the threshold for CaMKII activation, then an ultrasensitive “on switch” activates an extracellular signal-regulated kinase (ERK)-based positive feedback loop that triggers LTD instead. This postsynaptic feedback loop is sustained by another, trans-synaptic, feedback loop that maintains nitric oxide production throughout LTD induction. When full depression is achieved, an automatic “off switch” inactivates the feedback loops, returning the network to its basal state and demarcating the end of the early phase of LTD. | |||||
出版者 | ||||||
出版者 | Elsevier (Cell Press) | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29346769 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.celrep.2017.12.084 | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2211124717319216?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |