WEKO3
アイテム
{"_buckets": {"deposit": "95e7cea2-c877-4ba2-9452-8efc1d0bdb5d"}, "_deposit": {"created_by": 26, "id": "823", "owners": [26], "pid": {"revision_id": 0, "type": "depid", "value": "823"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00000823", "sets": ["25"]}, "author_link": ["4228", "4226", "4227"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-08-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "1549", "bibliographicPageStart": "1536", "bibliographicVolumeNumber": "24", "bibliographic_titles": [{}, {"bibliographic_title": "Cell Reports", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zang, Yunliang"}], "nameIdentifiers": [{"nameIdentifier": "4226", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Dieudonné, Stéphane"}], "nameIdentifiers": [{"nameIdentifier": "4227", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "De Schutter, Erik"}], "nameIdentifiers": [{"nameIdentifier": "4228", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. This makes the energy consumed during a complex spike (CS) also voltage dependent. PC dendrites exhibit inhomogeneous excitability with individual branches as computational units for CF input. The variability of somatic CSs can be explained by voltage state, CF activation phase, and instantaneous CF firing rate. Concurrent clustered synaptic inputs affect CSs by modulating dendritic responses in a spatially precise way. The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/30089264", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.celrep.2018.07.011", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.sciencedirect.com/science/article/pii/S221112471831088X?via%3Dihub", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": " © 2018 The Author(s)."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2211-1247", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-03-11"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "1-s2.0-S221112471831088X-main.pdf", "filesize": [{"value": "5.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution-NonCommercial-NoDerivatives License\n(http://creativecommons.org/Licenses/by-nc-nd/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 5000000.0, "url": {"label": "1-s2.0-S221112471831088X-main", "url": "https://oist.repo.nii.ac.jp/record/823/files/1-s2.0-S221112471831088X-main.pdf"}, "version_id": "7ad94b60-a110-45f7-9d2c-6d81cee77a9b"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "26", "path": ["25"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/823", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-03-11"}, "publish_date": "2019-03-11", "publish_status": "0", "recid": "823", "relation": {}, "relation_version_is_last": true, "title": ["Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells"], "weko_shared_id": 26}
Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells
https://oist.repo.nii.ac.jp/records/823
https://oist.repo.nii.ac.jp/records/8231b994e7f-a11b-4fe1-9b7a-4f1da4eccde2
名前 / ファイル | ライセンス | アクション |
---|---|---|
1-s2.0-S221112471831088X-main (5.0 MB)
|
Creative Commons Attribution-NonCommercial-NoDerivatives License
(http://creativecommons.org/Licenses/by-nc-nd/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-03-11 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zang, Yunliang
× Zang, Yunliang× Dieudonné, Stéphane× De Schutter, Erik |
|||||
書誌情報 |
en : Cell Reports 巻 24, 号 6, p. 1536-1549, 発行日 2018-08-07 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. This makes the energy consumed during a complex spike (CS) also voltage dependent. PC dendrites exhibit inhomogeneous excitability with individual branches as computational units for CF input. The variability of somatic CSs can be explained by voltage state, CF activation phase, and instantaneous CF firing rate. Concurrent clustered synaptic inputs affect CSs by modulating dendritic responses in a spatially precise way. The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals. | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30089264 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.celrep.2018.07.011 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S221112471831088X?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |