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Identification of depression subtypes and relevant brain regions using a data-driven approach
https://oist.repo.nii.ac.jp/records/824
https://oist.repo.nii.ac.jp/records/824181918bd-ed63-4eb7-8f9c-a8bc6de936e9
名前 / ファイル | ライセンス | アクション |
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s41598-018-32521-z (2.2 MB)
|
Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-03-11 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of depression subtypes and relevant brain regions using a data-driven approach | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Tokuda, Tomoki
× Tokuda, Tomoki× Yoshimoto, Junichiro× Shimizu, Yu× Okada, Go× Takamura, Masahiro× Okamoto, Yasumasa× Yamawaki, Shigeto× Doya, Kenji |
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書誌情報 |
en : Scientific Reports 巻 8, 号 1, p. 14082, 発行日 2018-09-20 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | It is well known that depressive disorder is heterogeneous, yet little is known about its neurophysiological subtypes. In the present study, we identified neurophysiological subtypes of depression related to specific neural substrates. We performed cluster analysis for 134 subjects (67 depressive subjects and 67 controls) using a high-dimensional dataset consisting of resting state functional connectivity measured by functional MRI, clinical questionnaire scores, and various biomarkers. Applying a newly developed, multiple co-clustering method to this dataset, we identified three subtypes of depression that are characterized by functional connectivity between the right Angular Gyrus (AG) and other brain areas in default mode networks, and Child Abuse Trauma Scale (CATS) scores. These subtypes are also related to Selective Serotonin-Reuptake Inhibitor (SSRI) treatment outcomes, which implies that we may be able to predict effectiveness of treatment based on AG-related functional connectivity and CATS. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30237567 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41598-018-32521-z | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41598-018-32521-z | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |