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Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing
https://oist.repo.nii.ac.jp/records/853
https://oist.repo.nii.ac.jp/records/85358c88711-3aea-40cd-a536-db8e3ff02959
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S0092867418308572-main (8.1 MB)
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Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-05-09 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Attig, Jan
× Attig, Jan× Agostini, Federico× Gooding, Clare× Chakrabarti, Anob M.× Singh, Aarti× Haberman, Nejc× Zagalak, Julian A.× Emmett, Warren× Smith, Christopher W.J.× Luscombe, Nicholas M.× Ule, Jernej |
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書誌情報 |
en : Cell 巻 174, 号 5, p. 1067-1081.e17, 発行日 2018-08-02 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins (RBPs) to introns. This includes MATR3, which promotes binding of PTBP1 to multivalent binding sites within LINEs. Both RBPs repress splicing and 3′ end processing within and around LINEs. Notably, repressive RBPs preferentially bind to evolutionarily young LINEs, which are located far from exons. These RBPs insulate the LINEs and the surrounding intronic regions from RNA processing. Upon evolutionary divergence, changes in RNA motifs within LINEs lead to gradual loss of their insulation. Hence, older LINEs are located closer to exons, are a common source of tissue-specific exons, and increasingly bind to RBPs that enhance RNA processing. Thus, LINEs are hubs for the assembly of repressive RBPs and also contribute to the evolution of new, lineage-specific transcripts in mammals. | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0092-8674 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1097-4172 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30078707 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.cell.2018.07.001 | |||||
権利 | ||||||
権利情報 | © 2018 The Authors. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0092867418308572?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |