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Nervous System Regionalization Entails Axial Allocation before Neural Differentiation
https://oist.repo.nii.ac.jp/records/935
https://oist.repo.nii.ac.jp/records/9351ff43a50-43be-4516-a312-d0c9f84cbaf2
名前 / ファイル | ライセンス | アクション |
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Metzis-2018-Nervous System Regionalization Ent (9.7 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Nervous System Regionalization Entails Axial Allocation before Neural Differentiation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Metzis, Vicki
× Metzis, Vicki× Steinhauser, Sebastian× Pakanavicius, Edvinas× Gouti, Mina× Stamataki, Despina× Ivanovitch, Kenzo× Watson, Thomas× Rayon, Teresa× Mousavy Gharavy, S. Neda× Lovell-Badge, Robin× Luscombe, Nicholas M.× Briscoe, James |
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書誌情報 |
en : Cell 巻 175, 号 4, p. 1105-1118.e17, 発行日 2018-10-18 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity; caudalizing signals then convert a proportion to posterior fates (spinal cord). To test this model, we used chromatin accessibility to define how cells adopt region-specific neural fates. Together with genetic and biochemical perturbations, this identified a developmental time window in which genome-wide chromatin-remodeling events preconfigure epiblast cells for neural induction. Contrary to the established model, this revealed that cells commit to a regional identity before acquiring neural identity. This "primary regionalization" allocates cells to anterior or posterior regions of the nervous system, explaining how cranial and spinal neurons are generated at appropriate axial positions. These findings prompt a revision to models of neural induction and support the proposed dual evolutionary origin of the vertebrate CNS. | |||||
出版者 | ||||||
出版者 | Elsevier Inc | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0092-8674 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1097-4172 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30343898 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.cell.2018.09.040 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0092867418312522?via%3Dihub | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.cell.com/cell/fulltext/S0092-8674(18)31252-2 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |