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Dendritic coincidence detection in Purkinje neurons of awake mice
https://oist.repo.nii.ac.jp/records/1930
https://oist.repo.nii.ac.jp/records/1930e3f6e388-35cc-4288-9a0e-304cb4b8803e
名前 / ファイル | ライセンス | アクション |
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Roome-2020-Dendritic coincidence detection in (5.9 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Dendritic coincidence detection in Purkinje neurons of awake mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Roome, Christopher J
× Roome, Christopher J× Kuhn, Bernd |
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書誌情報 |
en : eLife 巻 9, p. e59619, 発行日 2020-12-21 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Dendritic coincidence detection is fundamental to neuronal processing yet remains largely unexplored in awake animals. Specifically, the underlying dendritic voltage-calcium relationship has not been directly addressed. Here, using simultaneous voltage and calcium two-photon imaging of Purkinje neuron spiny dendrites, we show how coincident synaptic inputs and resulting dendritic spikes modulate dendritic calcium signaling during sensory stimulation in awake mice. Sensory stimulation increased the rate of postsynaptic potentials and dendritic calcium spikes evoked by climbing fiber and parallel fiber synaptic input. These inputs are integrated in a time-dependent and nonlinear fashion to enhance the sensory-evoked dendritic calcium signal. Intrinsic supralinear dendritic mechanisms, including voltage-gated calcium channels and metabotropic glutamate receptors, are recruited cooperatively to expand the dynamic range of sensory-evoked dendritic calcium signals. This establishes how dendrites can use multiple interplaying mechanisms to perform coincidence detection, as a fundamental and ongoing feature of dendritic integration in behaving animals. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33345779 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.59619 | |||||
権利 | ||||||
権利情報 | © 2020 Roome and Kuhn. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/59619 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |