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Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
https://oist.repo.nii.ac.jp/records/2367
https://oist.repo.nii.ac.jp/records/2367fb7c7a8a-56ef-492f-808f-f664bd957150
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S2589004221011196-main (3.9 MB)
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CC BY-NC-ND 4.0
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Takaoka, Shohei
× Takaoka, Shohei× Yanagiya, Akiko× Mohamed, Haytham Mohamed Aly× Higa, Rei× Abe, Takaya× Inoue, Ken-ichi× Takahashi, Akinori× Stoney, Patrick× Yamamoto, Tadashi |
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書誌情報 |
en : iScience 巻 24, 号 10, p. 103151, 発行日 2021-10-22 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity. The 5′–3′ exoribonuclease XRN1 executes the last step of RNA decay, but its physiological impact is not well understood. To address this, forebrain-specific Xrn1 conditional knockout mice (Xrn1-cKO) were generated, as Xrn1 null mice were embryonic lethal. Xrn1-cKO mice exhibited obesity with leptin resistance, hyperglycemia, hyperphagia, and decreased energy expenditure. Obesity resulted from dysregulated communication between the central nervous system and peripheral tissues. Moreover, expression of mRNAs encoding proteins that regulate appetite and energy expenditure was dysregulated in the hypothalamus of Xrn1-cKO mice. Therefore, we propose that XRN1 function in the hypothalamus is critical for maintenance of metabolic homeostasis. | |||||
出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2589-0042 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34646989 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.isci.2021.103151 | |||||
権利 | ||||||
権利情報 | © 2021 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2589004221011196 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |