WEKO3
アイテム
{"_buckets": {"deposit": "f9203f0e-56d9-4a55-9f37-2b8a666759a9"}, "_deposit": {"created_by": 32, "id": "2408", "owners": [32], "pid": {"revision_id": 0, "type": "depid", "value": "2408"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00002408", "sets": ["213"]}, "author_link": ["15978", "15976", "15984", "15980", "15977", "15979", "15982", "15981", "15983"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-10-27", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "101257", "bibliographicVolumeNumber": "15", "bibliographic_titles": [{}, {"bibliographic_title": "Translational Oncology", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kalra, Rajkumar S."}], "nameIdentifiers": [{"nameIdentifier": "15976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Soman, Gaurav S."}], "nameIdentifiers": [{"nameIdentifier": "15977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Parab, Pradeep B."}], "nameIdentifiers": [{"nameIdentifier": "15978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mali, Avinash M."}], "nameIdentifiers": [{"nameIdentifier": "15979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Varankar, Sagar S."}], "nameIdentifiers": [{"nameIdentifier": "15980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naik, Rutika R."}], "nameIdentifiers": [{"nameIdentifier": "15981", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamble, Swapnil C."}], "nameIdentifiers": [{"nameIdentifier": "15982", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Dhanjal, Jaspreet K."}], "nameIdentifiers": [{"nameIdentifier": "15983", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bapat, Sharmila A."}], "nameIdentifiers": [{"nameIdentifier": "15984", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "The involvement of cancer stem cells (CSCs) in driving tumor dormancy and drug resistance is well established. Most therapeutic regimens however are ineffective in targeting these regenerative populations. We report the development and evaluation of a monoclonal antibody, mAb150, which targets the metastasis associated antigen, Annexin A2 (AnxA2) through recognition of a N-terminal epitope. Treatment with mAb150 potentiated re-entry of CSCs into the cell cycle that perturbed tumor dormancy and facilitated targeting of CSCs as was validated by in vitro and in vivo assays. Epigenetic potentiation further improved mAb150 efficacy in achieving total tumor regression by targeting regenerative populations to achieve tumor regression, specifically in high-grade serous ovarian adenocarcinoma.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc. "}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/34715620", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.tranon.2021.101257", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.sciencedirect.com/science/article/pii/S1936523321002485?via%3Dihub", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2021 Elsevier Inc."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1936-5233", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-12-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "1-s2.0-S1936523321002485-main.pdf", "filesize": [{"value": "8.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 8000000.0, "url": {"label": "1-s2.0-S1936523321002485-main", "url": "https://oist.repo.nii.ac.jp/record/2408/files/1-s2.0-S1936523321002485-main.pdf"}, "version_id": "85d375ed-a3b6-4cd4-a6ec-83e5d89cc04c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Monoclonal antibody", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Annexin A2", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cancer stem cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Progenitors", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Epigenetic potentiation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Active cooperative cell migration", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "32", "path": ["213"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/2408", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-12-06"}, "publish_date": "2021-12-06", "publish_status": "0", "recid": "2408", "relation": {}, "relation_version_is_last": true, "title": ["A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors"], "weko_shared_id": 32}
A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors
https://oist.repo.nii.ac.jp/records/2408
https://oist.repo.nii.ac.jp/records/2408beb6777c-a44f-4f68-a531-dc89eaf0cea5
名前 / ファイル | ライセンス | アクション |
---|---|---|
1-s2.0-S1936523321002485-main (8.0 MB)
|
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-12-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Monoclonal antibody | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Annexin A2 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cancer stem cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Progenitors | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Epigenetic potentiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Active cooperative cell migration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kalra, Rajkumar S.
× Kalra, Rajkumar S.× Soman, Gaurav S.× Parab, Pradeep B.× Mali, Avinash M.× Varankar, Sagar S.× Naik, Rutika R.× Kamble, Swapnil C.× Dhanjal, Jaspreet K.× Bapat, Sharmila A. |
|||||
書誌情報 |
en : Translational Oncology 巻 15, 号 1, p. 101257, 発行日 2022-10-27 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The involvement of cancer stem cells (CSCs) in driving tumor dormancy and drug resistance is well established. Most therapeutic regimens however are ineffective in targeting these regenerative populations. We report the development and evaluation of a monoclonal antibody, mAb150, which targets the metastasis associated antigen, Annexin A2 (AnxA2) through recognition of a N-terminal epitope. Treatment with mAb150 potentiated re-entry of CSCs into the cell cycle that perturbed tumor dormancy and facilitated targeting of CSCs as was validated by in vitro and in vivo assays. Epigenetic potentiation further improved mAb150 efficacy in achieving total tumor regression by targeting regenerative populations to achieve tumor regression, specifically in high-grade serous ovarian adenocarcinoma. | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1936-5233 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34715620 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.tranon.2021.101257 | |||||
権利 | ||||||
権利情報 | © 2021 Elsevier Inc. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S1936523321002485?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |