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The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
https://oist.repo.nii.ac.jp/records/2734
https://oist.repo.nii.ac.jp/records/2734ba349697-594f-4c98-8406-20430e325bd7
名前 / ファイル | ライセンス | アクション |
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Haeggstrom-The clinically relevant CYP2C8_3 an (430.9 kB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-08-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Haeggström, Sigrid
× Haeggström, Sigrid× Ingelman-Sundberg, Magnus× Pääbo, Svante× Zeberg, Hugo |
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書誌情報 |
en : The Pharmacogenomics Journal 発行日 2022-07-02 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals. | |||||
出版者 | ||||||
出版者 | Nature Portfolio | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1470-269X | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1473-1150 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/35780191 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41397-022-00284-6 | |||||
権利 | ||||||
権利情報 | © 2022 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41397-022-00284-6 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |