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The choroid plexus is an important circadian clock component
https://oist.repo.nii.ac.jp/records/651
https://oist.repo.nii.ac.jp/records/651371af49b-5a0c-4bcd-bc42-d855e3c48dbb
名前 / ファイル | ライセンス | アクション |
---|---|---|
s41467-018-03507-2 (3.6 MB)
|
Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-08-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The choroid plexus is an important circadian clock component | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Myung, Jihwan
× Myung, Jihwan× Schmal, Christoph× Hong, Sungho× Tsukizawa, Yoshiaki× Rose, Pia× Zhang, Yong× Holtzman, Michael J.× De Schutter, Erik× Herzel, Hanspeter× Bordyugov, Grigory× Takumi, Toru |
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書誌情報 |
en : Nature Communications 巻 9, p. 1062, 発行日 2018-03-14 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN clocks to this hierarchy remains unclear. We examine circadian oscillations of clock gene expression in various brain loci and discovered that in mouse, robust, higher amplitude, relatively faster oscillations occur in the choroid plexus (CP) compared to the SCN. Our computational analysis and modeling show that the CP achieves these properties by synchronization of “twist” circadian oscillators via gap-junctional connections. Using an in vitro tissue coculture model and in vivo targeted deletion of the Bmal1 gene to silence the CP circadian clock, we demonstrate that the CP clock adjusts the SCN clock likely via circulation of cerebrospinal fluid, thus finely tuning behavioral circadian rhythms. | |||||
出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29540683 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-018-03507-2 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-018-03507-2 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |