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The Class-A GPCR Dopamine D2 Receptor Forms Transient Dimers Stabilized by Agonists: Detection by Single-Molecule Tracking
https://oist.repo.nii.ac.jp/records/768
https://oist.repo.nii.ac.jp/records/7688c020db3-06d7-436b-832c-b3e75b3dbbab
名前 / ファイル | ライセンス | アクション |
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Kasai-2018-The Class-A GPCR Dopamine D2 Recept (4.7 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-12-07 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Class-A GPCR Dopamine D2 Receptor Forms Transient Dimers Stabilized by Agonists: Detection by Single-Molecule Tracking | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kasai, Rinshi S.
× Kasai, Rinshi S.× Ito, Shuichi V.× Awane, Ryo M.× Fujiwara, Takahiro K.× Kusumi, Akihiro |
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書誌情報 |
en : Cell Biochemistry and Biophysics 巻 76, 号 1-2, p. 29-37, 発行日 2017-11-07 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Whether class-A G-protein coupled receptors (GPCRs) exist and work as monomers or dimers has drawn extensive attention. A class-A GPCR dopamine D2 receptor (D2R) is involved in many physiological and pathological processes and diseases, indicating its critical role in proper functioning of neuronal circuits. In particular, D2R homodimers might play key roles in schizophrenia development and amphetamine-induced psychosis. Here, using single-molecule imaging, we directly tracked single D2R molecules in the plasma membrane at a physiological temperature of 37 degrees C, and unequivocally determined that D2R forms transient dimers with a lifetime of 68 ms in its resting state. Agonist addition prolonged the dimer lifetime by a factor of ~1.5, suggesting the possibility that transient dimers might be involved in signaling. | |||||
出版者 | ||||||
出版者 | Springer US | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1559-0283 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29116599 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1007/s12013-017-0829-y | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://link.springer.com/article/10.1007%2Fs12013-017-0829-y | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |