{"created":"2023-06-26T11:00:30.486927+00:00","id":1008,"links":{},"metadata":{"_buckets":{"deposit":"34fd77e5-ec84-4f6a-9a00-d02f9e2faa67"},"_deposit":{"created_by":28,"id":"1008","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"1008"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001008","sets":["6:66"]},"author_link":["5540","5542","5539","5541","5543"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-01-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"854","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Teruya, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chaleckis, Romanas"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takada, Junko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagida, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondoh, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"During human fasting, metabolic markers, including butyrates, carnitines, and branched-chain amino acids, are upregulated for energy substitution through gluconeogenesis and use of stored lipids. We performed non-targeted, accurate semiquantitative metabolomic analysis of human whole blood, plasma, and red blood cells during 34-58 hr fasting of four volunteers. During this period, 44 of ~130 metabolites increased 1.5~60-fold. Consistently fourteen were previously reported. However, we identified another 30 elevated metabolites, implicating hitherto unrecognized metabolic mechanisms induced by fasting. Metabolites in pentose phosphate pathway are abundant, probably due to demand for antioxidants, NADPH, gluconeogenesis and anabolic metabolism. Global increases of TCA cycle-related compounds reflect enhanced mitochondrial activity in tissues during fasting. Enhanced purine/pyrimidine metabolites support RNA/protein synthesis and transcriptional reprogramming, which is promoted also by some fasting-related metabolites, possibly via epigenetic modulations. Thus diverse, pronounced metabolite increases result from greatly activated catabolism and anabolism stimulated by fasting. Anti-oxidation may be a principal response to fasting.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/30696848","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41598-018-36674-9","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-018-36674-9","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-10"}],"displaytype":"detail","filename":"Teruya-2019-Diverse metabolic reactions activa.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","license_note":"Creative Commons​\nAttribution 4.0 International​\n(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Teruya-2019-Diverse metabolic reactions activa","url":"https://oist.repo.nii.ac.jp/record/1008/files/Teruya-2019-Diverse metabolic reactions activa.pdf"},"version_id":"d6385019-019d-427f-b52c-189079aa8421"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["66"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-10"},"publish_date":"2019-07-10","publish_status":"0","recid":"1008","relation_version_is_last":true,"title":["Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T11:58:39.720739+00:00"}