{"created":"2023-06-26T11:00:30.822815+00:00","id":1013,"links":{},"metadata":{"_buckets":{"deposit":"8453775c-e89a-4ae3-a44e-4c90bbc183c5"},"_deposit":{"created_by":28,"id":"1013","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"1013"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001013","sets":["6:26"]},"author_link":["5572","5576","5570","5575","5573","5569","5580","5579","5578","5574","5581","5571","5577"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"18","bibliographicPageStart":"8","bibliographicVolumeNumber":"122","bibliographic_titles":[{},{"bibliographic_title":"Neurochemistry International","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Xinjian"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Taku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ahammad, Rijwan Uddin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuroda, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamuta, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yukinawa, Naoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Funahashi, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamahashi, Yukie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amano, Mutsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimoto, Junichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Kiyofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaibuchi, Kozo"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Medium spiny neurons (MSNs) expressing dopamine D1 receptor (D1R) or D2 receptor (D2R) are major components of the striatum. Stimulation of D1R activates protein kinase A (PKA) through Golf to increase neuronal activity, while D2R stimulation inhibits PKA through Gi. Adenosine A2A receptor (A2AR) coupled to Golf is highly expressed in D2R-MSNs within the striatum. However, how dopamine and adenosine co-operatively regulate PKA activity remains largely unknown. Here, we measured Rap1gap serine 563 phosphorylation to monitor PKA activity and examined dopamine and adenosine signals in MSNs. We found that a D1R agonist increased Rap1gap phosphorylation in striatal slices and in D1R-MSNs in vivo. A2AR agonist CGS21680 increased Rap1gap phosphorylation, and pretreatment with the D2R agonist quinpirole blocked this effect in striatal slices. D2R antagonist eticlopride increased Rap1gap phosphorylation in D2R-MSNs in vivo, and the effect of eticlopride was blocked by the pretreatment with the A2AR antagonist SCH58261. These results suggest that adenosine positively regulates PKA in D2R-MSNs through A2AR, while this effect is blocked by basal dopamine in vivo. Incorporating computational model analysis, we propose that the shift from D1R-MSNs to D2R-MSNs or vice versa appears to depend predominantly on a change in dopamine concentration.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/30336179","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.neuint.2018.10.008","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S0197018618302900","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2018 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0197-0186","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-10"}],"displaytype":"detail","filename":"1-s2.0-S0197018618302900-main.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","license_note":"Creative Commons​\nAttribution 4.0 International​\n(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1-s2.0-S0197018618302900-main","url":"https://oist.repo.nii.ac.jp/record/1013/files/1-s2.0-S0197018618302900-main.pdf"},"version_id":"59b7e18e-2b9a-4874-9513-046c5f8d539f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-10"},"publish_date":"2019-07-10","publish_status":"0","recid":"1013","relation_version_is_last":true,"title":["Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T11:58:31.858209+00:00"}