@phdthesis{oai:oist.repo.nii.ac.jp:00001113,
 author = {Mekhail, Simon Peter},
 month = {2020-09-30, 2019-10-02},
 note = {Parkinson's disease is a debilitating and potentially life-threatening disorder which manifests as a malfunction of dopamine producing cells in the basal ganglia of the brain. While the disease was first described over 200 years ago, this cell death remains poorly understood. Since the turn of the millennium functional labeling has enabled all-optical probing and stimulation of neuronal activity. This has greatly aided neuroscience research, yet a key hurdle remains for access to the basal ganglia; cortical scattering. To deliver light to the basal ganglia in a controlled way, the work contained in this thesis uses thin implants for imaging in-vivo.
Three main experiments are discussed. The first involves imaging with a fiber bundle and graded index lens and is split into two parts. In the first part, the low resolution inherent to fiber bundles is somewhat overcome by using compressive sensing, a data processing technique which allows sub-Nyquist sampling by exploiting sparsity in the signal. In the second part, the method is adapted for in-vivo calcium imaging in behaving mice. The second experiment addresses methods by which the relatively large, graded index lens implant may be replaced by a short section of multimode fiber. While this technique has a smaller footprint for a given field-of-view, the temporal resolution suffers slightly as scanning is required. Finally, the third experiment addresses measurement and excitation of specific modes in few-mode fibers by means of a spatial light modulator. Whereas this technique was initially investigated for fiber imaging for neuronal purposes it was deemed unsuitable for imaging in behaving mice due to the bend sensitivity of the fiber. Therfore the method was adapted for use on a different platform, namely optical nanofibers for studies on cold atom interactions with the evanescent fields of the nanofiber modes.},
 school = {Okinawa Institute of Science and Technology Graduate University},
 title = {生体内神経用の圧縮マイクロ内視鏡とナノファイバーでのモード分析のための光ファイバープローブ},
 year = {}
}