@article{oai:oist.repo.nii.ac.jp:00001177,
 author = {Pasha, Maira and Sohail, Muhammad and Tanaka, Fujie},
 issue = {1},
 journal = {HETEROCYCLES},
 month = {Aug},
 note = {Spirooxindole derivatives are found in bioactive natural products and are used in drug discovery and related research. Here, acid-catalyzed diastereoselective intramolecular oxa-Michael cyclization reactions of β-hydroxyenones generated from enones and isatin derivatives that afford spirooxindole tetrahydropyranes are reported. The major diastereomers of the products of these reactions were previously difficult to access by the amine-catalyzed hetero-Diels-Alder reactions of enones with isatins. With the use of enantiomerically enriched forms of the starting materials in the reactions, enantiomerically enriched spirooxindole tetrahydropyranes that retained the enantiopurities of the starting materials were obtained.},
 pages = {339--346},
 title = {Intramolecular Oxa-Michael Reactions of Aldols Generated from Enones and Isatins to Afford Spirooxindole Tetrahydropyrans},
 volume = {101},
 year = {2019}
}