{"created":"2023-06-26T11:00:39.055375+00:00","id":1178,"links":{},"metadata":{"_buckets":{"deposit":"52b15981-d1dd-48ff-9d76-b3d55310a85a"},"_deposit":{"created_by":29,"id":"1178","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"1178"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001178","sets":["6:66"]},"author_link":["6533","6534","6535"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"190125","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"Open Biology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakazawa, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arakawa, Orie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagida, Mitsuhiro"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Condensin is an essential component of chromosome dynamics, including mitotic chromosome condensation and segregation, DNA repair, and development. Genome-wide localization of condensin is known to correlate with transcriptional activity. The functional relationship between condensin accumulation and transcription sites remains unclear, however. By constructing the auxin-inducible degron strain of condensin, herein we demonstrate that condensin does not affect transcription itself. Instead, RNA-processing at transcriptional termination appears to define condensin accumulation sites during mitosis, in the fission yeast Schizosaccharomyces pombe. Combining the auxin-degron strain with the nda3 β-tubulin cold-sensitive (cs) mutant enabled us to inactivate condensin in mitotically arrested cells, without releasing the cells into anaphase. Transcriptional activation and termination were not affected by condensin's degron-mediated depletion, at heat-shock inducible genes or mitotically activated genes. On the other hand, condensin accumulation sites shifted approximately 500 bp downstream in the auxin-degron of 5′-3′ exoribonuclease Dhp1, in which transcripts became aberrantly elongated, suggesting that condensin accumulates at transcriptionally terminated DNA regions. Growth defects in mutant strains of 3′-processing ribonuclease and polyA cleavage factors were additive in condensin temperature-sensitive (ts) mutants. Considering condensin's in vitro activity to form double-stranded DNAs from unwound, single-stranded DNAs or DNA-RNA hybrids, condensin-mediated processing of mitotic transcripts at the 3′-end may be a prerequisite for faithful chromosome segregation.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Royal Society"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/31615333","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1098/rsob.190125","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://royalsocietypublishing.org/doi/10.1098/rsob.190125","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2046-2441","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-17"}],"displaytype":"detail","filename":"Nakazawa-2019-Condensin locates at transcripti.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) ","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Nakazawa-2019-Condensin locates at transcripti","url":"https://oist.repo.nii.ac.jp/record/1178/files/Nakazawa-2019-Condensin locates at transcripti.pdf"},"version_id":"c57fa2c4-a0bc-4683-b3ec-b1fffd26d36a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"29","path":["66"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-17"},"publish_date":"2020-02-17","publish_status":"0","recid":"1178","relation_version_is_last":true,"title":["Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts"],"weko_creator_id":"29","weko_shared_id":29},"updated":"2023-06-26T11:55:34.318998+00:00"}