{"created":"2023-06-26T11:00:41.111677+00:00","id":1220,"links":{},"metadata":{"_buckets":{"deposit":"7d124f73-4593-4cfe-8f39-1dd40cbc3110"},"_deposit":{"created_by":27,"id":"1220","owners":[27],"pid":{"revision_id":0,"type":"depid","value":"1220"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001220","sets":["6:175"]},"author_link":["6726","6727","6725","6728"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"1496","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Nutrients","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tominaga, Takaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ma, Sihui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saitou, Kumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Katsuhiko"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Carbohydrate (CHO) supplementation during exercise attenuates exercise-induced increases in plasma Interleukin (IL)-6 concentration. However, the effects of CHO supplementation on muscle IL-6 production during endurance exercise is controversial. The purpose of this study was to investigate the effects of CHO supplementation on muscle IL-6 production during endurance exercise with a special focus on the IL-6 producing cells. \nMETHODS: C57BL/6J mice were divided into three groups-sedentary with water ingestion group as the control (Con; n = 10), exercise with water ingestion group (Ex; n = 10), and exercise with 6% glucose ingestion group (Ex + glucose; n = 10). The Ex and Ex + glucose groups completed 3 h of treadmill running (24 m/min, 7% incline) and were sacrificed immediately after exercise. \nRESULTS: The exercise-induced increases of plasma IL-6 concentration and gastrocnemius IL-6 gene expression were attenuated by glucose ingestion. However, the increases of soleus IL-6 gene expression and gastrocnemius and soleus IL-6 protein expression were not attenuated by glucose ingestion. Furthermore, we observed that macrophages that infiltrated muscle produce IL-6 and glucose ingestion attenuated the infiltration of IL-6-producing macrophages. CONCLUSION: This study revealed that infiltrating macrophages may be one type of IL-6-producing cells during endurance exercise, and the infiltration of these cells in muscle was attenuated by glucose ingestion. However, the effects of glucose ingestion on muscle IL-6 production were limited.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/31262006","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3390/nu11071496","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/2072-6643/11/7/1496/htm","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6643","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-04"}],"displaytype":"detail","filename":"Tominaga-2019-Glucose Ingestion Inhibits Endur.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International \n(https://creativecommons.org/licenses/by/4.0/) ","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Tominaga-2019-Glucose Ingestion Inhibits Endur","url":"https://oist.repo.nii.ac.jp/record/1220/files/Tominaga-2019-Glucose Ingestion Inhibits Endur.pdf"},"version_id":"9d754dc3-a583-4970-b551-7dc6139a485a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"27","path":["175"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-04"},"publish_date":"2020-03-04","publish_status":"0","recid":"1220","relation_version_is_last":true,"title":["Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle"],"weko_creator_id":"27","weko_shared_id":27},"updated":"2023-06-26T11:54:57.983519+00:00"}