{"created":"2023-06-26T11:00:41.204830+00:00","id":1222,"links":{},"metadata":{"_buckets":{"deposit":"d11a8bfa-9f14-46b7-bafa-d0f1f0670083"},"_deposit":{"created_by":29,"id":"1222","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"1222"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001222","sets":["6:63"]},"author_link":["6730","6736","6734","6735","6731","6733","6732","6729"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageEnd":"7382","bibliographicPageStart":"7376","bibliographicVolumeNumber":"35","bibliographic_titles":[{},{"bibliographic_title":"Langmuir","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Du, Enming"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hu, Xunwu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Guanying"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Shijin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mang, Dingze"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Roy, Sona"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Ye"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Inspired by the metamorphosis of pore-forming toxins from soluble inactive monomers to cytolytic trans-membrane assemblies, we developed self-assembly-directed membrane insertion of synthetic analogues for permeability alteration. An expanded pi-conjugation-based molecular precursor with an extremely high rigidity and a long hydrophobic length that is comparable to the hydrophobic width of plasma membrane was synthesized for membrane-inserted self-assembly. Guided by the cancer biomarker expression in vitro, the soluble precursors transform into hydrophobic monomers forming assemblies inserted into the fluid phase of the membrane exclusively. Membrane insertion of rigid synthetic analogues destroys the selective permeability of the plasma membrane gradually. It eventually leads to cancer cell death, including drug resistant cancer cells.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"American Chemical Society"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/30091933","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1021/acs.langmuir.8b02107","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acs.langmuir.8b02107","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2018 American Chemical Society　"},{"subitem_rights":"This document is the Accepted Manuscript version of a Published Work that appeared in final form in Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Analogues for Permeability Alteration, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see https://pubs.acs.org/doi/10.1021/acs.langmuir.8b02107."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0743-7463","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1520-5827","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-09"}],"displaytype":"detail","filename":"Langmuir-emd.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Langmuir-emd","url":"https://oist.repo.nii.ac.jp/record/1222/files/Langmuir-emd.pdf"},"version_id":"987d2e2c-a86c-4072-9b43-c3d9356f1ff5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Analogues for Permeability Alteration","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Analogues for Permeability Alteration","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"29","path":["63"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-04"},"publish_date":"2020-03-04","publish_status":"0","recid":"1222","relation_version_is_last":true,"title":["Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Analogues for Permeability Alteration"],"weko_creator_id":"29","weko_shared_id":29},"updated":"2023-06-26T11:54:56.919042+00:00"}