@article{oai:oist.repo.nii.ac.jp:00001224,
 author = {Ashworth, William and Stoney, Patrick N. and Yamamoto, Tadashi},
 journal = {Current Opinion in Systems Biology},
 month = {Mar},
 note = {An appropriate equilibrium between transcription and mRNA decay is vital for the function of the cell. The RNA-binding complexes regulating mRNA degradation, such as carbon catabolite repression 4-negative on TATA-less, may also control several other stages of the mRNA life cycle, from transcription to translation. This pleiotropic control complicates the analysis of mRNA stability. Computational models have analysed the mechanisms underlying mRNA turnover and have been used to extract mRNA decay rates from high-throughput data sets. Multiomics studies have clarified the actions of RNA-binding complexes, and such studies allow the evolution of more accurate and complex computational models. This review discusses two complementary aspects of systems biology in the study of mRNA decay—computational modelling of mRNA turnover and recent ‘-omics’ studies of the function of RNA-binding proteins controlling mRNA stability.},
 pages = {48--57},
 title = {States of decay: The systems biology of mRNA stability},
 volume = {15},
 year = {2019}
}