@article{oai:oist.repo.nii.ac.jp:00001369,
 author = {Schunter, Celia and Ravasi, Timothy and Munday, Philip L and Nilsson, Göran E},
 issue = {1},
 journal = {Conservation Physiology},
 month = {Dec},
 note = {Maladaptive behavioural disturbances have been reported in some fishes and aquatic invertebrates exposed to projected future CO2 levels. These disturbances have been linked to altered ion gradients and neurotransmitter function in the brain. Still, it seems surprising that the relatively small ionic changes induced by near-future CO2 levels can have such profound neural effects. Based on recent transcriptomics data, we propose that a vicious cycle can be triggered that amplifies the initial disturbance, explaining how small pH regulatory adjustments in response to ocean acidification can lead to major behavioural alterations in fish and other water-breathing animals. The proposed cycle is initiated by a reversal of the function of some inhibitory GABAA receptors in the direction of neural excitation and then amplified by adjustments in gene expression aimed at suppressing the excitation but in reality increasing it. In addition, the increased metabolic production of CO2 by overexcited neurons will feed into the cycle by elevating intracellular bicarbonate levels that will lead to increased excitatory ion fluxes through GABAA receptors. We also discuss the possibility that an initiation of a vicious cycle could be one of the several factors underlying the differences in neural sensitivity to elevated CO2 displayed by fishes.},
 title = {Neural effects of elevated CO2 in fish may be amplified by a vicious cycle},
 volume = {7},
 year = {2019}
}