{"created":"2023-06-26T11:00:46.888131+00:00","id":1369,"links":{},"metadata":{"_buckets":{"deposit":"c1b203a7-3e35-44e6-88b0-8bb385649fb4"},"_deposit":{"created_by":30,"id":"1369","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1369"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001369","sets":["6:189"]},"author_link":["7885","7884","7883","7886"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"coz100","bibliographicVolumeNumber":"7","bibliographic_titles":[{},{"bibliographic_title":"Conservation Physiology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Schunter, Celia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ravasi, Timothy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Munday, Philip L"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nilsson, Göran E"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Maladaptive behavioural disturbances have been reported in some fishes and aquatic invertebrates exposed to projected future CO2 levels. These disturbances have been linked to altered ion gradients and neurotransmitter function in the brain. Still, it seems surprising that the relatively small ionic changes induced by near-future CO2 levels can have such profound neural effects. Based on recent transcriptomics data, we propose that a vicious cycle can be triggered that amplifies the initial disturbance, explaining how small pH regulatory adjustments in response to ocean acidification can lead to major behavioural alterations in fish and other water-breathing animals. The proposed cycle is initiated by a reversal of the function of some inhibitory GABAA receptors in the direction of neural excitation and then amplified by adjustments in gene expression aimed at suppressing the excitation but in reality increasing it. In addition, the increased metabolic production of CO2 by overexcited neurons will feed into the cycle by elevating intracellular bicarbonate levels that will lead to increased excitatory ion fluxes through GABAA receptors. We also discuss the possibility that an initiation of a vicious cycle could be one of the several factors underlying the differences in neural sensitivity to elevated CO2 displayed by fishes.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"},{"subitem_publisher":"Society for Experimental Biology"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/31832196","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1093/conphys/coz100","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/conphys/article/7/1/coz100/5669866","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2051-1434","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-21"}],"displaytype":"detail","filename":"Schunter-2019-Neural effects of elevated CO2 i.pdf","filesize":[{"value":"537.3 kB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Schunter-2019-Neural effects of elevated CO2 i","url":"https://oist.repo.nii.ac.jp/record/1369/files/Schunter-2019-Neural effects of elevated CO2 i.pdf"},"version_id":"abf2ec2b-ef20-4e46-8198-e7b616e87780"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neural effects of elevated CO2 in fish may be amplified by a vicious cycle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neural effects of elevated CO2 in fish may be amplified by a vicious cycle","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["189"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-21"},"publish_date":"2020-04-21","publish_status":"0","recid":"1369","relation_version_is_last":true,"title":["Neural effects of elevated CO2 in fish may be amplified by a vicious cycle"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:52:18.219601+00:00"}