@article{oai:oist.repo.nii.ac.jp:00001384,
 author = {Zhang, Dongxin and Chen, Yan and Cai, Hu and Yin, Lei and Zhong, Junchao and Man, Jingjing and Zhang, Qian-Feng and Bethi, Venkati and Tanaka, Fujie},
 issue = {1},
 journal = {Organic Letters},
 month = {Nov},
 note = {Direct asymmetric synthesis of δ-hydroxy-β-ketoesters was accomplished via regio- and enantioselective aldol reactions of β-ketoesters with isatins catalyzed by cinchona alkaloid thiourea derivatives. The C–C bond formation of the reactions occurred only at the γ-position of the β-ketoesters. Reaction progress monitoring and product stability analyses under the conditions that included the catalyst indicated that the γ-position reaction products were formed kinetically. Various δ-hydroxy-β-ketoesters bearing 3-alkyl-3-hydroxyoxindole cores relevant to the development of bioactive molecules were synthesized.},
 pages = {6--10},
 title = {Direct Catalytic Asymmetric Synthesis of Oxindole-Derived δ-Hydroxy-β-ketoesters by Aldol Reactions},
 volume = {22},
 year = {2019}
}