@article{oai:oist.repo.nii.ac.jp:00001409,
 author = {Chiba, Shuntaro and Ohue, Masahito and Gryniukova, Anastasiia and Borysko, Petro and Zozulya, Sergey and Yasuo, Nobuaki and Yoshino, Ryunosuke and Ikeda, Kazuyoshi and Shin, Woong-Hee and Kihara, Daisuke and Iwadate, Mitsuo and Umeyama, Hideaki and Ichikawa, Takaaki and Teramoto, Reiji and Hsin, Kun-Yi and Gupta, Vipul and Kitano, Hiroaki and Sakamoto, Mika and Higuchi, Akiko and Miura, Nobuaki and Yura, Kei and Mochizuki, Masahiro and Ramakrishnan, Chandrasekaran and Thangakani, A. Mary and Velmurugan, D. and Gromiha, M. Michael and Nakane, Itsuo and Uchida, Nanako and Hakariya, Hayase and Tan, Modong and Nakamura, Hironori K. and Suzuki, Shogo D. and Ito, Tomoki and Kawatani, Masahiro and Kudoh, Kentaroh and Takashina, Sakurako and Yamamoto, Kazuki Z. and Moriwaki, Yoshitaka and Oda, Keita and Kobayashi, Daisuke and Okuno, Tatsuya and Minami, Shintaro and Chikenji, George and Prathipati, Philip and Nagao, Chioko and Mohsen, Attayeb and Ito, Mari and Mizuguchi, Kenji and Honma, Teruki and Ishida, Takashi and Hirokawa, Takatsugu and Akiyama, Yutaka and Sekijima, Masakazu},
 issue = {1},
 journal = {Scientific Reports},
 month = {Dec},
 note = {Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods and scoring. Our aim was to identify target enzyme inhibitors and to benchmark computer-aided drug discovery methods under the same experimental conditions. Collecting compound lists derived from various methods is advantageous for aggregating compounds with structurally diversified properties compared with the use of a single method. The inhibitory action on Sirtuin 1 of approximately half of the proposed compounds was experimentally accessed. Ultimately, seven structurally diverse compounds were identified.},
 title = {A prospective compound screening contest identified broader inhibitors for Sirtuin 1},
 volume = {9},
 year = {2019}
}