{"created":"2023-06-26T11:00:49.189010+00:00","id":1409,"links":{},"metadata":{"_buckets":{"deposit":"83e91d29-df93-4589-9490-a722fb0b32a2"},"_deposit":{"created_by":30,"id":"1409","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1409"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001409","sets":["6:36"]},"author_link":["8540","8556","8568","8538","8572","8558","8565","8544","8546","8548","8549","8571","8532","8564","8536","8534","8567","8582","8541","8552","8547","8560","8575","8581","8550","8531","8535","8559","8561","8551","8570","8557","8580","8579","8578","8573","8577","8563","8543","8553","8554","8574","8539","8533","8542","8555","8537","8576","8545","8562","8566","8530","8569"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"19585","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chiba, Shuntaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohue, Masahito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gryniukova, Anastasiia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Borysko, Petro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zozulya, Sergey"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuo, Nobuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshino, Ryunosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Kazuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shin, Woong-Hee"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kihara, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwadate, Mitsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umeyama, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichikawa, Takaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Teramoto, Reiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hsin, Kun-Yi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gupta, Vipul"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitano, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Mika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higuchi, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Nobuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yura, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mochizuki, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ramakrishnan, Chandrasekaran"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Thangakani, A. Mary"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Velmurugan, D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gromiha, M. Michael"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Itsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Nanako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hakariya, Hayase"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tan, Modong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Hironori K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Shogo D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawatani, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kudoh, Kentaroh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takashina, Sakurako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Kazuki Z."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriwaki, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oda, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okuno, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minami, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chikenji, George"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Prathipati, Philip"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagao, Chioko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mohsen, Attayeb"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizuguchi, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honma, Teruki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishida, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirokawa, Takatsugu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekijima, Masakazu"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods and scoring. Our aim was to identify target enzyme inhibitors and to benchmark computer-aided drug discovery methods under the same experimental conditions. Collecting compound lists derived from various methods is advantageous for aggregating compounds with structurally diversified properties compared with the use of a single method. The inhibitory action on Sirtuin 1 of approximately half of the proposed compounds was experimentally accessed. Ultimately, seven structurally diverse compounds were identified.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Research "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/31863054","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41598-019-55069-y","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-019-55069-y","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-27"}],"displaytype":"detail","filename":"s41598-019-55069-y.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41598-019-55069-y","url":"https://oist.repo.nii.ac.jp/record/1409/files/s41598-019-55069-y.pdf"},"version_id":"a54562d4-6a8a-4606-a349-aec2573c1e20"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A prospective compound screening contest identified broader inhibitors for Sirtuin 1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A prospective compound screening contest identified broader inhibitors for Sirtuin 1","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-27"},"publish_date":"2020-04-27","publish_status":"0","recid":"1409","relation_version_is_last":true,"title":["A prospective compound screening contest identified broader inhibitors for Sirtuin 1"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:51:17.745858+00:00"}