{"created":"2023-06-26T11:00:54.801376+00:00","id":1505,"links":{},"metadata":{"_buckets":{"deposit":"05698b37-77c5-44d1-8ef2-0c0d46e9cf9a"},"_deposit":{"created_by":28,"id":"1505","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"1505"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001505","sets":["6:89"]},"author_link":["9119","9114","9121","9116","9111","9117","9112","9118","9120","9113","9110","9115"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"53.e4","bibliographicPageStart":"44","bibliographicVolumeNumber":"28","bibliographic_titles":[{},{"bibliographic_title":"Structure","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takizawa, Yoshimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ho, Cheng-Han"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tachiwana, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsunami, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Wataru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Midori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arimura, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hori, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukagawa, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohi, Melanie D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wolf, Matthias"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurumizaka, Hitoshi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The histone H3 variant CENP-A is a crucial epigenetic marker for centromere specification. CENP-A forms a characteristic nucleosome and dictates the higher-order configuration of centromeric chromatin. However, little is known about how the CENP-A nucleosome affects the architecture of centromeric chromatin. In this study, we reconstituted tri-nucleosomes mimicking a centromeric nucleosome arrangement containing the CENP-A nucleosome, and determined their 3D structures by cryoelectron microscopy. The H3-CENP-A-H3 tri-nucleosomes adopt an untwisted architecture, with an outward-facing linker DNA path between nucleosomes. This is distinct from the H3-H3-H3 tri-nucleosome architecture, with an inward-facing DNA path. Intriguingly, the untwisted architecture may allow the CENP-A nucleosome to be exposed to the solvent in the condensed chromatin model. These results provide a structural basis for understanding the 3D configuration of CENP-A-containing chromatin, and may explain how centromeric proteins can specifically target the CENP-A nucleosomes buried in robust amounts of H3 nucleosomes in centromeres.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/31711756","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.str.2019.10.016","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S0969212619303570","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"This article/chapter was published in Structure, Volume 28, Issue 1, Yoshimasa Takizawa, Cheng-Han Ho, Hiroaki Tachiwana, Hideyuki Matsunami, Wataru Kobayashi, Midori Suzuki, Yasuhiro Arimura, Tetsuya Hori, Tatsuo Fukagawa, Melanie D. Ohi, Matthias Wolf, Hitoshi Kurumizaka, Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome, 44-53.e4, © 2019 Elsevier Ltd."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-2126","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1878-4186","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-08"}],"displaytype":"detail","filename":"Takizawa,Structure,main_text_102119_final.pdf","filesize":[{"value":"534.2 kB"}],"format":"application/pdf","license_note":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Takizawa,Structure,main_text_102119_final","url":"https://oist.repo.nii.ac.jp/record/1505/files/Takizawa,Structure,main_text_102119_final.pdf"},"version_id":"2f993613-f78d-46d3-b2c1-7fdf1778d183"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-08"}],"displaytype":"detail","filename":"Takizawa,Structure,Supplemental_Figure.pdf","filesize":[{"value":"768.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Takizawa,Structure,Supplemental_Figure","url":"https://oist.repo.nii.ac.jp/record/1505/files/Takizawa,Structure,Supplemental_Figure.pdf"},"version_id":"dacc5251-e0f4-45e1-ae3e-c595ef4b5d73"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"centromere","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CENP-A chromatin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cryo-EM","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nucleosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histone variant","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["89"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-15"},"publish_date":"2020-05-15","publish_status":"0","recid":"1505","relation_version_is_last":true,"title":["Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T11:44:17.657231+00:00"}