@article{oai:oist.repo.nii.ac.jp:00001522, author = {Hashimoto, Takuya and Kozone, Ikuko and Hashimoto, Junko and Ueoka, Reiko and Kagaya, Noritaka and Fujie, Manabu and Sato, Noriyuki and Ikeda, Haruo and Shin-ya, Kazuo}, issue = {3}, journal = {The Journal of Antibiotics}, month = {Dec}, note = {In the course of our studies on the heterologous expression of giant biosynthetic genes, we discovered a novel cryptic biosynthetic gene cluster in Streptomyces rochei IFO12908. During our efforts to express biosynthetic genes using the host SUKA strain derived from Streptomyces avermitilis, a novel polyene macrolactam compound designated as JBIR-156 was produced. We report herein the cloning and heterologous expression of the JBIR-156 biosynthetic gene cluster, and the isolation, structure determination, and cytotoxic activity of this novel compound.}, pages = {171--174}, title = {Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908}, volume = {73}, year = {2019} }