{"created":"2023-06-26T11:00:55.733168+00:00","id":1522,"links":{},"metadata":{"_buckets":{"deposit":"a4d4b829-f4da-425e-9c45-180cfd9deaf3"},"_deposit":{"created_by":29,"id":"1522","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"1522"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001522","sets":["6:165","6:51"]},"author_link":["9236","9235","9241","9237","9234","9239","9242","9238","9240"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"174","bibliographicPageStart":"171","bibliographicVolumeNumber":"73","bibliographic_titles":[{},{"bibliographic_title":"The Journal of Antibiotics","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashimoto, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kozone, Ikuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashimoto, Junko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueoka, Reiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kagaya, Noritaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujie, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Noriyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Haruo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shin-ya, Kazuo"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In the course of our studies on the heterologous expression of giant biosynthetic genes, we discovered a novel cryptic biosynthetic gene cluster in Streptomyces rochei IFO12908. During our efforts to express biosynthetic genes using the host SUKA strain derived from Streptomyces avermitilis, a novel polyene macrolactam compound designated as JBIR-156 was produced. We report herein the cloning and heterologous expression of the JBIR-156 biosynthetic gene cluster, and the isolation, structure determination, and cytotoxic activity of this novel compound.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/31853031","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41429-019-0265-x","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41429-019-0265-x","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s), under exclusive licence to the Japan Antibiotics Research Association"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-8820","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1881-1469","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-18"}],"displaytype":"detail","filename":"Manuscript_revised_final_200524.pdf","filesize":[{"value":"520.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Manuscript_revised_final_200524","url":"https://oist.repo.nii.ac.jp/record/1522/files/Manuscript_revised_final_200524.pdf"},"version_id":"9a9447b2-865b-46b0-a657-85a201e65777"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-18"}],"displaytype":"detail","filename":"41429_2019_265_MOESM1_ESM.pdf","filesize":[{"value":"932.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"41429_2019_265_MOESM1_ESM","url":"https://oist.repo.nii.ac.jp/record/1522/files/41429_2019_265_MOESM1_ESM.pdf"},"version_id":"2d03f595-b0c6-4fba-805a-eec59907f4dd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"29","path":["51","165"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-22"},"publish_date":"2020-05-22","publish_status":"0","recid":"1522","relation_version_is_last":true,"title":["Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908"],"weko_creator_id":"29","weko_shared_id":29},"updated":"2023-06-26T11:48:47.974291+00:00"}