{"created":"2023-06-26T11:00:56.640546+00:00","id":1540,"links":{},"metadata":{"_buckets":{"deposit":"8328da4e-97b3-4fe0-acc6-3ee37a42a71f"},"_deposit":{"created_by":26,"id":"1540","owners":[26],"pid":{"revision_id":0,"type":"depid","value":"1540"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001540","sets":["6:68"]},"author_link":["9323","9329","9325","9327","9330","9326","9324","9328","9322"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"122","bibliographicVolumeNumber":"2","bibliographic_titles":[{},{"bibliographic_title":"Communications Chemistry","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mackay, Sean M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Myint, David Mo Aung"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Easingwood, Richard A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hegh, Dylan Y."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wickens, Jeffery R."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hyland, Brian I."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jameson, Guy N. L."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Reynolds, John N. J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tan, Eng Wui"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The unique surface plasmon resonance of hollow gold nanoshells can be used to achieve drug release from liposomes upon laser stimulation, and adapted to mimic the intricate dynamics of neurotransmission ex vivo in brain preparations. However, to induce a physiological response in vivo requires the degree of temporal precision afforded by laser stimulation, but with a greater depth of penetration through tissue. Here we report that the attachment of hollow gold nanoshells to the surface of robust liposomes results in a construct that is highly sensitive to ultrasonic stimulation. The resulting construct can be remotely triggered by low intensity, therapeutic ultrasound. To our knowledge, this is the first example of nanoparticle-liposome system that can be activated by both laser and acoustic stimulation. The system is capable of encapsulating the neurochemical dopamine, and repeatedly releasing small amounts on-demand in a circulating environment, allowing for precise spatiotemporal control over the release profile.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s42004-019-0226-0","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s42004-019-0226-0","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s). "}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2399-3669","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-10"}],"displaytype":"detail","filename":"Mackay-2019-Dynamic control of neurochemical r.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International\n(http://creativecommons.org/licenses/by/4.0/) ","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Mackay-2019-Dynamic control of neurochemical r","url":"https://oist.repo.nii.ac.jp/record/1540/files/Mackay-2019-Dynamic control of neurochemical r.pdf"},"version_id":"f64b2615-4156-4b87-9be4-9e9c28af0e29"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"26","path":["68"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-10"},"publish_date":"2020-06-10","publish_status":"0","recid":"1540","relation_version_is_last":true,"title":["Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes"],"weko_creator_id":"26","weko_shared_id":26},"updated":"2023-06-26T11:48:32.646340+00:00"}