@article{oai:oist.repo.nii.ac.jp:00001555,
 author = {Furukawa, Emi and Bado, Patricia and Tripp, Gail and Mattos, Paulo and Wickens, Jeff R. and Bramati, Ivanei E. and Alsop, Brent and Ferreira, Fernanda Meireles and Lima, Debora and Tovar-Moll, Fernanda and Sergeant, Joseph A. and Moll, Jorge},
 issue = {2},
 journal = {PLoS ONE},
 month = {Feb},
 note = {Altered reward processing has been proposed to contribute to the symptoms of attention deficit hyperactivity disorder (ADHD). The neurobiological mechanism underlying this alteration remains unclear. We hypothesize that the transfer of dopamine release from reward to reward-predicting cues, as normally observed in animal studies, may be deficient in ADHD. Functional magnetic resonance imaging (fMRI) was used to investigate striatal responses to reward-predicting cues and reward delivery in a classical conditioning paradigm. Data from 14 high-functioning and stimulant-naïve young adults with elevated lifetime symptoms of ADHD (8 males, 6 females) and 15 well-matched controls (8 males, 7 females) were included in the analyses. During reward anticipation, increased blood-oxygen-level-dependent (BOLD) responses in the right ventral and left dorsal striatum were observed in controls, but not in the ADHD group. The opposite pattern was observed in response to reward delivery; the ADHD group demonstrated significantly greater BOLD responses in the ventral striatum bilaterally and the left dorsal striatum relative to controls. In the ADHD group, the number of current hyperactivity/impulsivity symptoms was inversely related to ventral striatal responses during reward anticipation and positively associated with responses to reward. The BOLD response patterns observed in the striatum are consistent with impaired predictive dopamine signaling in ADHD, which may explain altered reward-contingent behaviors and symptoms of ADHD.},
 title = {Abnormal Striatal BOLD Responses to Reward Anticipation and Reward Delivery in ADHD},
 volume = {9},
 year = {2014}
}