{"created":"2023-06-26T11:00:57.549382+00:00","id":1555,"links":{},"metadata":{"_buckets":{"deposit":"76535b4b-9448-4789-b6a6-a995dc5e5cd1"},"_deposit":{"created_by":26,"id":"1555","owners":[26],"pid":{"revision_id":0,"type":"depid","value":"1555"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001555","sets":["6:62","6:68"]},"author_link":["9408","9411","9416","9412","9406","9414","9417","9410","9407","9415","9409","9413"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"e89129","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Furukawa, Emi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bado, Patricia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tripp, Gail"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mattos, Paulo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wickens, Jeff R."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bramati, Ivanei E."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Alsop, Brent"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ferreira, Fernanda Meireles"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lima, Debora"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tovar-Moll, Fernanda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sergeant, Joseph A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moll, Jorge"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Altered reward processing has been proposed to contribute to the symptoms of attention deficit hyperactivity disorder (ADHD). The neurobiological mechanism underlying this alteration remains unclear. We hypothesize that the transfer of dopamine release from reward to reward-predicting cues, as normally observed in animal studies, may be deficient in ADHD. Functional magnetic resonance imaging (fMRI) was used to investigate striatal responses to reward-predicting cues and reward delivery in a classical conditioning paradigm. Data from 14 high-functioning and stimulant-naïve young adults with elevated lifetime symptoms of ADHD (8 males, 6 females) and 15 well-matched controls (8 males, 7 females) were included in the analyses. During reward anticipation, increased blood-oxygen-level-dependent (BOLD) responses in the right ventral and left dorsal striatum were observed in controls, but not in the ADHD group. The opposite pattern was observed in response to reward delivery; the ADHD group demonstrated significantly greater BOLD responses in the ventral striatum bilaterally and the left dorsal striatum relative to controls. In the ADHD group, the number of current hyperactivity/impulsivity symptoms was inversely related to ventral striatal responses during reward anticipation and positively associated with responses to reward. The BOLD response patterns observed in the striatum are consistent with impaired predictive dopamine signaling in ADHD, which may explain altered reward-contingent behaviors and symptoms of ADHD.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/24586543","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1371/journal.pone.0089129","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089129","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2014 Furukawa et al."},{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-19"}],"displaytype":"detail","filename":"Furukawa-2014-Abnormal striatal BOLD responses.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution License\n","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Furukawa-2014-Abnormal striatal BOLD responses","url":"https://oist.repo.nii.ac.jp/record/1555/files/Furukawa-2014-Abnormal striatal BOLD responses.pdf"},"version_id":"53be4684-326f-4e21-ba3d-bcfa0f75f356"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Abnormal Striatal BOLD Responses to Reward Anticipation and Reward Delivery in ADHD","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Abnormal Striatal BOLD Responses to Reward Anticipation and Reward Delivery in ADHD","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"26","path":["62","68"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-19"},"publish_date":"2020-06-19","publish_status":"0","recid":"1555","relation_version_is_last":true,"title":["Abnormal Striatal BOLD Responses to Reward Anticipation and Reward Delivery in ADHD"],"weko_creator_id":"26","weko_shared_id":26},"updated":"2023-06-26T11:48:02.217568+00:00"}