{"created":"2023-06-26T11:00:59.926319+00:00","id":1608,"links":{},"metadata":{"_buckets":{"deposit":"4dfc1a4b-c3b2-492d-a497-b99b9df47211"},"_deposit":{"created_by":30,"id":"1608","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1608"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001608","sets":["6:64","6:67"]},"author_link":["9637","9629","9628","9633","9638","9636","9632","9635","9630","9634","9627","9631","9639"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"e201900494","bibliographicVolumeNumber":"3","bibliographic_titles":[{},{"bibliographic_title":"Life Science Alliance","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Akinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soeda, Shou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaoka, Shohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobori, Shungo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Tomokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mohamed, Haytham Mohamed Aly"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagiya, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Takaya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shigeta, Mayo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuta, Yasuhide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuba, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Tadashi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The biological significance of deadenylation in global gene expression is not fully understood. Here, we show that the CCR4-NOT deadenylase complex maintains expression of mRNAs, such as those encoding transcription factors, cell cycle regulators, DNA damage response-related proteins, and metabolic enzymes, at appropriate levels in the liver. Liver-specific disruption of Cnot1, encoding a scaffold subunit of the CCR4-NOT complex, leads to increased levels of mRNAs for transcription factors, cell cycle regulators, and DNA damage response-related proteins because of reduced deadenylation and stabilization of these mRNAs. CNOT1 suppression also results in an increase of immature, unspliced mRNAs (pre-mRNAs) for apoptosis-related and inflammation-related genes and promotes RNA polymerase II loading on their promoter regions. In contrast, mRNAs encoding metabolic enzymes become less abundant, concomitant with decreased levels of these pre-mRNAs. Lethal hepatitis develops concomitantly with abnormal mRNA expression. Mechanistically, the CCR4-NOT complex targets and destabilizes mRNAs mainly through its association with Argonaute 2 (AGO2) and butyrate response factor 1 (BRF1) in the liver. Therefore, the CCR4-NOT complex contributes to liver homeostasis by modulating the liver transcriptome through mRNA deadenylation.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Life Science Alliance"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32238456","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.26508/lsa.201900494","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.life-science-alliance.org/content/3/5/e201900494","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 Takahashi et al."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2575-1077","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-07"}],"displaytype":"detail","filename":"e201900494.full.pdf","filesize":[{"value":"8.4 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"e201900494.full","url":"https://oist.repo.nii.ac.jp/record/1608/files/e201900494.full.pdf"},"version_id":"8633ec3d-b57e-4b93-8b21-39c15ee1555f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["64","67"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-08"},"publish_date":"2020-07-08","publish_status":"0","recid":"1608","relation_version_is_last":true,"title":["The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:46:50.618380+00:00"}