@article{oai:oist.repo.nii.ac.jp:00001630, author = {Vojkovsky, Tomas and Deolka, Shubham and Stepanova, Saiyyna and Roy, Michael C. and Khaskin, Eugene}, issue = {12}, journal = {ACS Catalysis}, month = {Apr}, note = {Sulfones and sulfonamides with an α-CH bond can be easily alkylated by aliphatic alcohols to add the carbon skeleton of the alcohol via a one-step, Ru(II)-catalyzed redox neutral reaction. The reaction requires a substoichiometric amount of base and produces only water as a byproduct. Several pharmaceutically relevant functional groups such as piperidine, morpholine, etc. are well-tolerated under the reaction conditions to give higher value-added products in one step from widely available substrates. The reaction proceeds through a sulfone carbanion addition to an in-situ-generated aldehyde formed via catalytic dehydrogenation and subsequent catalyst-mediated replacement of the secondary alcohol by hydrogen.}, pages = {6810--6815}, title = {Catalytic Sulfone Upgrading Reaction with Alcohols via Ru(II)}, volume = {10}, year = {2020} }