{"created":"2023-06-26T11:01:01.205234+00:00","id":1631,"links":{},"metadata":{"_buckets":{"deposit":"33d88b44-1b59-469f-ac78-a12f7313007b"},"_deposit":{"created_by":30,"id":"1631","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1631"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001631","sets":["6:52"]},"author_link":["9790","9791","9786","9789","9788","9787"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"3224","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Le, Ngoc Tu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harukawa, Yoshiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Saori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Boer, Damian"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawabe, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saze, Hidetoshi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In plants, epigenetic regulation is critical for silencing transposons and maintaining proper gene expression. However, its impact on the genome-wide transcription initiation landscape remains elusive. By conducting a genome-wide analysis of transcription start sites (TSSs) using cap analysis of gene expression (CAGE) sequencing, we show that thousands of TSSs are exclusively activated in various epigenetic mutants of Arabidopsis thaliana and referred to as cryptic TSSs. Many have not been identified in previous studies, of which up to 65% are contributed by transposons. They possess similar genetic features to regular TSSs and their activation is strongly associated with the ectopic recruitment of RNAPII machinery. The activation of cryptic TSSs significantly alters transcription of nearby TSSs, including those of genes important for development and stress responses. Our study, therefore, sheds light on the role of epigenetic regulation in maintaining proper gene functions in plants by suppressing transcription from cryptic TSSs.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature research"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32591528","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41467-020-16951-w","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-020-16951-w#article-info","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-17"}],"displaytype":"detail","filename":"Le-2020-Epigenetic regulation of spurious tran.pdf","filesize":[{"value":"5.8 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Le-2020-Epigenetic regulation of spurious tran","url":"https://oist.repo.nii.ac.jp/record/1631/files/Le-2020-Epigenetic regulation of spurious tran.pdf"},"version_id":"281d7c11-748e-4169-8527-513fa7e1284a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Epigenetic regulation of spurious transcription initiation in Arabidopsis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Epigenetic regulation of spurious transcription initiation in Arabidopsis","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["52"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-17"},"publish_date":"2020-07-17","publish_status":"0","recid":"1631","relation_version_is_last":true,"title":["Epigenetic regulation of spurious transcription initiation in Arabidopsis"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:46:16.827581+00:00"}