{"created":"2023-06-26T11:01:02.641406+00:00","id":1657,"links":{},"metadata":{"_buckets":{"deposit":"019dea0b-8ff2-4d1d-9081-9b35539f7d25"},"_deposit":{"created_by":29,"id":"1657","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"1657"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001657","sets":["6:218"]},"author_link":["9945","9943","9941","9940","9942","9939","9944"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"e1008869","bibliographicVolumeNumber":"16","bibliographic_titles":[{},{"bibliographic_title":"PLOS Genetics","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Deveau, Ciana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jiao, Xiaodong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Sachihiro C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Krishnakumar, Asha"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimatsu, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hejtmancik, J Fielding"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nelson, Ralph F."}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"We investigate mutations in trbeta2, a splice variant of thrb, identifying changes in function, structure, and behavior in larval and adult zebrafish retinas. Two N-terminus CRISPR mutants were identified. The first is a 6BP+1 insertion deletion frameshift resulting in a truncated protein. The second is a 3BP in frame deletion with intact binding domains. ERG recordings of isolated cone signals showed that the 6BP+1 mutants did not respond to red wavelengths of light while the 3BP mutants did respond. 6BP+1 mutants lacked optomotor and optokinetic responses to red/black and green/black contrasts. Both larval and adult 6BP+1 mutants exhibit a loss of red-cone contribution to the ERG and an increase in UV-cone contribution. Transgenic reporters show loss of cone trbeta2 activation in the 6BP+1 mutant but increase in the density of cones with active blue, green, and UV opsin genes. Antibody reactivity for red-cone LWS1 and LWS2 opsin was absent in the 6BP+1 mutant, as was reactivity for arrestin3a. Our results confirm a critical role for trbeta2 in long-wavelength cone development.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32569302","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1371/journal.pgen.1008869","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/publicdomain/zero/1.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008869","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1553-7404","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1553-7390","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-31"}],"displaytype":"detail","filename":"journal.pgen.1008869.pdf","filesize":[{"value":"7.3 MB"}],"format":"application/pdf","license_note":"Creative Commons CC0 1.0 Universal(https://creativecommons.org/publicdomain/zero/1.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"journal.pgen.1008869","url":"https://oist.repo.nii.ac.jp/record/1657/files/journal.pgen.1008869.pdf"},"version_id":"36264d01-59b9-43cb-9249-28e89ba1e2a2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"29","path":["218"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-31"},"publish_date":"2020-07-31","publish_status":"0","recid":"1657","relation_version_is_last":true,"title":["Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)"],"weko_creator_id":"29","weko_shared_id":29},"updated":"2023-06-26T11:45:35.471404+00:00"}