@article{oai:oist.repo.nii.ac.jp:00001682,
 author = {Bonetti, Alessandro and Agostini, Federico and Suzuki, Ana Maria and Hashimoto, Kosuke and Pascarella, Giovanni and Gimenez, Juliette and Roos, Leonie and Nash, Alex J. and Ghilotti, Marco and Cameron, Christopher J.  F. and Valentine, Matthew and Medvedeva, Yulia A. and Noguchi, Shuhei and Agirre, Eneritz and Kashi, Kaori and Samudyata and Luginbühl, Joachim and Cazzoli, Riccardo and Agrawal, Saumya and Luscombe, Nicholas M. and Blanchette, Mathieu and Kasukawa, Takeya and Hoon, Michiel de and Arner, Erik and Lenhard, Boris and Plessy, Charles and Castelo-Branco, Gonçalo and Orlando, Valerio and Carninci, Piero},
 issue = {1},
 journal = {Nature Communications},
 month = {Feb},
 note = {Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. To investigate the function of such RNAs, methods to massively map the genomic interacting sites of multiple transcripts have been developed; however, these methods have some limitations. Here, we introduce RNA And DNA Interacting Complexes Ligated and sequenced (RADICL-seq), a technology that maps genome-wide RNA-chromatin interactions in intact nuclei. RADICL-seq is a proximity ligation-based methodology that reduces the bias for nascent transcription, while increasing genomic coverage and unique mapping rate efficiency compared with existing methods. RADICL-seq identifies distinct patterns of genome occupancy for different classes of transcripts as well as cell type-specific RNA-chromatin interactions, and highlights the role of transcription in the establishment of chromatin structure.},
 title = {RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions},
 volume = {11},
 year = {2020}
}