{"created":"2023-06-26T11:01:04.090698+00:00","id":1684,"links":{},"metadata":{"_buckets":{"deposit":"5cb9f95e-b20c-431c-96a0-e7557bf7ae96"},"_deposit":{"created_by":30,"id":"1684","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1684"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001684","sets":["6:67"]},"author_link":["10139","10142","10137","10140","10134","10135","10136","10138","10141"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"698","bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"Cancers","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kim, Eun Ho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kim, Mi-Sook"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Akihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uzawa, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimori, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Osteosarcoma(OSA)isthemostcommonmalignantbonetumorinchildrenandadolescents. The overall five-year survival rate for all bone cancers is below 70%; however, when the cancer has spread beyond the bone, it is about 15–30%. Herein, we evaluated the effects of carbon-ion beam irradiation alone or in combination with zoledronic acid (ZOL) on OSA cells. Carbon-ion beam irradiation in combination with ZOL significantly inhibited OSA cell proliferation by arresting cell cycle progression and initiating KHOS and U2OS cell apoptosis, compared to treatments with carbon-ion beam irradiation, X-ray irradiation, and ZOL alone. Moreover, we observed that this combination greatly inhibited OSA cell motility and invasion, accompanied by the suppression of the Pi3K/Akt and MAPK signaling pathways, which are related to cell proliferation and survival, compared to individual treatments with carbon-ion beam or X-ray irradiation, or ZOL. Furthermore, ZOL treatment upregulated microRNA (miR)-29b expression; the combination with a miR-29b mimic further decreased OSA cell viability via activation of the caspase 3 pathway. Thus, ZOL-mediated enhancement of carbon-ion beam radiosensitivity may occur via miR-29b upregulation; co-treatment with the miR-29b mimic further decreased OSA cell survival. These findings suggest that the carbon-ion beam irradiation in combination with ZOL has high potential to increase OSA cell death.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"MDPI "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32187978","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3390/cancers12030698","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/2072-6694/12/3/698","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6694","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-19"}],"displaytype":"detail","filename":"Kim-2020-Carbon-Ion Beam Irradiation Alone or.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Kim-2020-Carbon-Ion Beam Irradiation Alone or","url":"https://oist.repo.nii.ac.jp/record/1684/files/Kim-2020-Carbon-Ion Beam Irradiation Alone or.pdf"},"version_id":"b0040d41-09dc-430a-909a-fc2c122637c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"zoledronic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteosarcoma cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone cance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carbon-ion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miR-29b","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["67"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-19"},"publish_date":"2020-08-19","publish_status":"0","recid":"1684","relation_version_is_last":true,"title":["Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:45:01.712073+00:00"}