{"created":"2023-06-26T11:01:06.115245+00:00","id":1719,"links":{},"metadata":{"_buckets":{"deposit":"973ff1d0-8ec4-4877-99f7-c27bb2c352ba"},"_deposit":{"created_by":29,"id":"1719","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"1719"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001719","sets":["6:67"]},"author_link":["10333","10335","10332","10340","10337","10336","10334","10331","10338","10339"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-24","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"261","bibliographicPageStart":"253","bibliographicVolumeNumber":"150","bibliographic_titles":[{},{"bibliographic_title":"Radiotherapy and Oncology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ahire, Vidhula"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sunada, Shigeaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ho Kim, Eun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chevalier, François"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Romeo, Paul-Henri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Tadashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saintigny, Yannick"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Background and purpose\nHigh-grade chondrosarcomas are chemo- and radio-resistant cartilage-forming tumors of bone that often relapse and metastase. Thus, new therapeutic strategies are urgently needed.\n\nMaterial and methods\nChondrosarcoma cells (CH-2879) were exposed to carbon-ion irradiation, combined with miR-34 mimic and/or rapamycin administration. The effects of treatment on cancer stem cells, stemness-associated phenotype, radioresistance and tumor-initiating properties were evaluated.\n\nResults\nWe show that high-grade chondrosarcoma cells contain a population of radioresistant cancer stem cells that can be targeted by a combination of carbon-ion therapy, miR-34 mimic administration and/or rapamycin treatment that triggers FOXO3 and miR-34 over-expression. mTOR inhibition by rapamycin triggered FOXO3 and miR-34, leading to KLF4 repression.\n\nConclusion\nOur results show that particle therapy combined with molecular treatments effectively controls cancer stem cells and may overcome treatment resistance of high-grade chondrosarcoma.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32717360","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.radonc.2020.07.034","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.radonc.2020.07.034","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"This article/chapter was published in Journal of Radiotherapy and Oncology, Volume 150, Guillaume Vares, Vidhula Ahire, Shigeaki Sunada, Eun Ho Kim, Sei Sai, François Chevalier, Paul-Henri Romeo, Tadashi Yamamoto, Tetsuo Nakajima, Yannick Saintigny, A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells, 253-261, © Elsevier 2020."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0167-8140","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-24"}],"displaytype":"detail","filename":"VARES Accepted Manuscript.pdf","filesize":[{"value":"8.2 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"VARES Accepted Manuscript","url":"https://oist.repo.nii.ac.jp/record/1719/files/VARES Accepted Manuscript.pdf"},"version_id":"df9e5882-7764-4372-adfa-6e05d03d1bc3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cancer stem cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chondrosarcoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Particle therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mTOR inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miR-34","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"29","path":["67"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-09"},"publish_date":"2020-10-09","publish_status":"0","recid":"1719","relation_version_is_last":true,"title":["A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells"],"weko_creator_id":"29","weko_shared_id":29},"updated":"2023-06-26T11:43:59.122142+00:00"}